Results 111 to 120 of about 6,440,759 (285)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
UAV Path Planning With QoS Constraint in Device-to-Device 5G Networks Using Particle Swarm Optimization [PDF]
, 2020 Lin Shi, Shoukun Xu
openalex +1 more source
A machine learning‐based approach to the multiobjective optimization of CO2 injection and water production during CCS in a saline aquifer based on field data [PDF]
, 2023 Pouya Vaziri, Behnam Sedaee
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Self-Adaptive Hybridized Lion Optimization Algorithm With Transfer Learning for Ancient Tamil Character Recognition in Stone Inscriptions [PDF]
, 2023 R. Devi Priya +7 more
openalex +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Microscopically based energy density functionals for nuclei using the density matrix expansion: Implementation and pre-optimization [PDF]
, 2010 M. V. Stoitsov +6 more
openalex +1 more source