Results 131 to 140 of about 5,593,327 (347)
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Cultural Sociology, 2011 Drawing on material from a broad range of fields, this article identifies an ‘optimism of everyday life’ and proposes that it performs significant psychological, social and cultural functions. These functions are briefly reviewed, with particular reference to psychological and physical health, family and social relationships and the achievement of ...
openaire +3 more sources
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
Scientific ReportsUtilization of optimization technique is a must in the design of contemporary antenna systems. Often, global search methods are necessary, which are associated with high computational costs when conducted at the level of full-wave electromagnetic (EM ...
Slawomir Koziel +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Journal of Modern Power Systems and Clean Energy, 2018 Distributed photovoltaic generators (DPGs) have been integrated into the medium/low voltage distribution network widely. Due to the randomness and fluctuation of DPG, however, the distribution and direction of power flow are changed frequently on some ...
Bin LI +3 more
doaj +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
ePyDGGA: automatic configuration for fitting epidemic curves
Scientific ReportsMany epidemiological models and algorithms are used to fit the parameters of a given epidemic curve. On many occasions, fitting algorithms are interleaved with the actual epidemic models, which yields combinations of model-parameters that are hard to ...
Josep Alòs +5 more
doaj +1 more source
Efficient Gradient-Enhanced Bayesian Optimizer with Comparisons to Quasi-Newton Optimizers for Unconstrained Local Optimization [PDF]
arXivThe probabilistic surrogates used by Bayesian optimizers make them popular methods when function evaluations are noisy or expensive to evaluate. While Bayesian optimizers are traditionally used for global optimization, their benefits are also valuable for local optimization.
arxiv