Results 41 to 50 of about 3,624,996 (285)
Mathematics, 2022 This article considers a box-constrained global optimization problem for Lipschitz continuous functions with an unknown Lipschitz constant. The well-known derivative-free global search algorithm DIRECT (DIvide RECTangle) is a promising approach for such ...
Linas Stripinis, Remigijus Paulavičius
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
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Theoretical Computer Science, 1996 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gu Xunrang, Zhu Yuzhang
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On the Optimization of Dijkstra’s Algorithm [PDF]
, 2011 In this paper, we propose some amendment on Dijkstras algorithm in order to optimize it by reducing the number of iterations. The main idea is to solve the problem where more than one node satisfies the condition of the second step in the traditional Dijkstras algorithm.
Seifedine Nimer Kadry +2 more
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Niching genetic algorithms for optimization in electromagnetics. II. Shape optimization of electrodes using the CSM [PDF]
, 1998 In this paper, we present a new approach for automatic design of electrodes. The investigated method consists in identifying an optimal shape from an optimal equipotential resulting from a system of point charges.
Sareni, Bruno +2 more
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Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
A High-Performance Stochastic Fractal Search Algorithm for Optimal Generation Dispatch Problem
Energies, 2019 This paper proposes applications of a modified stochastic fractal search algorithm (MSFS) to solve the economic load dispatch problem (ELD) in which valve-point effects, prohibited operating zones, power losses in all conductors, multi-fuel sources and ...
Ly Huu Pham +4 more
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