Results 101 to 110 of about 19,096,786 (283)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Development of Multimodal Fusion Technology for Tomato Maturity Assessment

Sensors
The maturity of fruits and vegetables such as tomatoes significantly impacts indicators of their quality, such as taste, nutritional value, and shelf life, making maturity determination vital in agricultural production and the food processing industry ...
Yang Liu, Chaojie Wei, Seung-Chul Yoon, Xinzhi Ni, Wei Wang, Yizhe Liu, Daren Wang, Xiaorong Wang, Xiaohuan Guo   +8 more
doaj   +1 more source

An Experimental Evaluation of Bayesian Optimization on Bipedal Locomotion

, 2013
© 2014 IEEE.The design of gaits and corresponding control policies for bipedal walkers is a key challenge in robot locomotion. Even when a viable controller parametrization already exists, finding near-optimal parameters can be daunting.
Calandra, R, Deisenroth, MP, Peters, J, Seyfarth, A   +3 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Sizing and Optimization Language (SOL): A computer language to improve the user/optimizer interface [PDF]

The nonlinear mathematical programming method (formal optimization) has had many applications in engineering design. A figure illustrates the use of optimization techniques in the design process. The design process begins with the design problem, such as
Lucas, S. H., Scotti, S. J.
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment

Frontiers in Microbiology, 2017
Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic infections in immuno-compromised individuals. Due to its multiple resistances toward antibiotics, the development of new drugs is required.
Giuseppe Allegretta, Christine K. Maurer, Jens Eberhard, Damien Maura, Damien Maura, Damien Maura, Rolf W. Hartmann, Rolf W. Hartmann, Laurence Rahme, Laurence Rahme, Laurence Rahme, Martin Empting   +11 more
doaj   +1 more source

Optimization Design and Application of Active Disturbance Rejection Controller Based on Intelligent Algorithm

IEEE Access, 2019
The parameter tuning optimization design is realized for an active disturbance rejection controller (ADRC) in combination with the improvement of the existing swarm intelligence algorithm.
Chaohai Kang, Siqi Wang, Weijian Ren, Yang Lu, Boyu Wang   +4 more
semanticscholar   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Metallic nanomedicine in cancer immunotherapy

Acta Pharmaceutica Sinica B
Immunotherapy has become a pivotal modality in clinical cancer treatment. However, its effectiveness is limited to a small subset of patients due to the low antigenicity, impaired innate response, and various adaptive immune resistance mechanisms of the ...
Shixuan Li, Xiaohu Wang, Huiyun Han, Shuting Xiang, Mingxi Li, Guangyu Long, Yanming Xia, Qiang Zhang, Suxin Li   +8 more
doaj   +1 more source