Results 81 to 90 of about 2,303,688 (304)

Analysis-of-marginal-Tail-Means (ATM): a robust method for discrete black-box optimization

, 2018
We present a new method, called Analysis-of-marginal-Tail-Means (ATM), for effective robust optimization of discrete black-box problems. ATM has important applications to many real-world engineering problems (e.g., manufacturing optimization, product ...
Mak, Simon, Wu, C. F. Jeff
core   +2 more sources

Efficient design optimization of complex electromagnetic systems using parametric macromodeling techniques [PDF]

, 2011
We propose a new parametric macromodeling technique for complex electromagnetic systems described by scattering parameters, which are parameterized by multiple design variables such as layout or substrate feature.
Antonini, Giulio, Dhaene, Tom, Ferranti, Francesco, Knockaert, Luc, Scogna, Antonio Ciccomancini   +4 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib‐Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency

Advanced Science
Overcoming acquired resistance to Osimertinib remains a critical challenge in treating NSCLC. This research indicates that Osimertinib‐resistant cells exhibit a strong dependence on glutamine metabolism.
Jiali Huang, Xiankang Zhang, Hui Zhang, Yu Li, Huidan Huang, Zhiyu Li, Zhixia Qiu, Hongxi Wu, Dechun Huang, Xi Xu, Jinlei Bian   +10 more
doaj   +1 more source

An Experimental Evaluation of Bayesian Optimization on Bipedal Locomotion

, 2013
© 2014 IEEE.The design of gaits and corresponding control policies for bipedal walkers is a key challenge in robot locomotion. Even when a viable controller parametrization already exists, finding near-optimal parameters can be daunting.
Calandra, R, Deisenroth, MP, Peters, J, Seyfarth, A   +3 more
core   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Discovery of New Ti-Based Alloys Aimed at Avoiding/Minimizing Formation of α” and ω-Phase Using CALPHAD and Artificial Intelligence

Metals, 2020
In this work, we studied a Ti-Nb-Zr-Sn system for exploring novel composition and temperatures that will be helpful in maximizing the stability of β phase while minimizing the formation of α” and ω-phase. The Ti-Nb-Zr-Sn system is free of toxic elements.
Rajesh Jha, George S. Dulikravich
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A CIA Triad-Based Taxonomy of Prompt Attacks on Large Language Models

Future Internet
The rapid proliferation of Large Language Models (LLMs) across industries such as healthcare, finance, and legal services has revolutionized modern applications.
Nicholas Jones, Md Whaiduzzaman, Tony Jan, Amr Adel, Ammar Alazab, Afnan Alkreisat   +5 more
doaj   +1 more source