Results 111 to 120 of about 19,096,786 (283)

Design of High Temperature Ti–Al–Cr–V Alloys for Maximum Thermodynamic Stability Using Self-Organizing Maps

open access: yesMetals, 2019
Data generated for the Ti−Al−Cr−V system of metallic alloys from our previous publication, where the composition of 102 alloys were computationally Pareto optimized with the objective of simultaneously maximizing the Young’s ...
Rajesh Jha, George S. Dulikravich
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

BayesOpt: A Bayesian Optimization Library for Nonlinear Optimization, Experimental Design and Bandits [PDF]

open access: yes, 2014
BayesOpt is a library with state-of-the-art Bayesian optimization methods to solve nonlinear optimization, stochastic bandits or sequential experimental design problems.
Martinez-Cantin, Ruben
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Stability Analysis of Neural Networks-Based System Identification

open access: yesModelling and Simulation in Engineering, 2008
This paper treats some problems related to nonlinear systems identification. A stability analysis neural network model for identifying nonlinear dynamic systems is presented.
Talel Korkobi   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Large-Scale Multi-Antenna Multi-Sine Wireless Power Transfer

open access: yes, 2017
Wireless Power Transfer (WPT) is expected to be a technology reshaping the landscape of low-power applications such as the Internet of Things, Radio Frequency identification (RFID) networks, etc.
Clerckx, Bruno, Huang, Yang
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Conceptual design optimization study [PDF]

open access: yes
The feasibility of applying multilevel functional decomposition and optimization techniques to conceptual design of advanced fighter aircraft was investigated.
Beeman, E. R., II   +2 more
core   +1 more source

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