Results 81 to 90 of about 799,975 (268)

Algebraic Methods for Optimization Problems [PDF]

, 2002
We argue for the benefits of relations over functions for modelling programs, and even more so for modelling specifications. To support this argument, we present an extended case study for a class of optimization problems, deriving efficient functional programs from concise relational specifications.
Richard S. Bird, Jeremy Gibbons, Shin-Cheng Mu   +2 more
openaire   +4 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Application of Gradient Optimization Methods in Defining Neural Dynamics

Axioms
Applications of gradient method for nonlinear optimization in development of Gradient Neural Network (GNN) and Zhang Neural Network (ZNN) are investigated.
Predrag S. Stanimirović, Nataša Tešić, Dimitrios Gerontitis, Gradimir V. Milovanović, Milena J. Petrović, Vladimir L. Kazakovtsev, Vladislav Stasiuk   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Analog Network-Coded Modulation With Maximum Euclidean Distance: Mapping Criterion and Constellation Design

IEEE Access, 2017
Physical-layer network coding holds the great potential of improving the power efficiency and the spectral efficiency for the two-stage transmission scheme. The first stage is the multiple access stage, where two source nodes (SN1 and SN2) simultaneously
Zhijiang Yu, Wei Chen, Xin Guo, Xiang Chen, Chen Sun   +4 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A Family of Gradient Methods for Optimization [PDF]

The Computer Journal, 1970
The approaches to the problem of maximising or minimising a nonlinear function of several variables can be put into three categories according to how much information is extracted from the function. 1. Only the function value. The more well-known methods in this category are those of Nelder and Mead (1965), Powell (1965), Rosenbrock (1960), and Swann ...
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

A Review on Economic Dispatch of Power System Considering Atmospheric Pollutant Emissions

Energies
The environmental/economic dispatch (EED) of power systems addresses the environmental pollution problems caused by power generation at the operational level, offering macroscopic control without requiring additional construction and remediation costs ...
Hengzhen Wang, Ying Xu, Zhongkai Yi, Jianing Xu, Yilin Xie, Zhimin Li   +5 more
doaj   +1 more source