Results 81 to 90 of about 808,313 (268)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Analog Network-Coded Modulation With Maximum Euclidean Distance: Mapping Criterion and Constellation Design

IEEE Access, 2017
Physical-layer network coding holds the great potential of improving the power efficiency and the spectral efficiency for the two-stage transmission scheme. The first stage is the multiple access stage, where two source nodes (SN1 and SN2) simultaneously
Zhijiang Yu, Wei Chen, Xin Guo, Xiang Chen, Chen Sun   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Review on Economic Dispatch of Power System Considering Atmospheric Pollutant Emissions

Energies
The environmental/economic dispatch (EED) of power systems addresses the environmental pollution problems caused by power generation at the operational level, offering macroscopic control without requiring additional construction and remediation costs ...
Hengzhen Wang, Ying Xu, Zhongkai Yi, Jianing Xu, Yilin Xie, Zhimin Li   +5 more
doaj   +1 more source

Game Theoretical Modelling of Network/Cybersecurity

IEEE Access, 2019
Game theory is an established branch of mathematics that offers a rich set of mathematical tools for multi-person strategic decision making that can be used to model the interactions of decision makers in security problems who compete for limited and ...
Azhar Iqbal, Lachlan J. Gunn, Mingyu Guo, M. Ali Babar, Derek Abbott   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Design method of high-flux lead-bismuth cooled reactor neutron flux maximization based on BP neural network

He jishu
BackgroundThe development of high-throughput reactors is of great significance for supporting the development of nuclear science and technology, improving the efficiency of nuclear energy utilization, meeting the needs of radioactive isotope production ...
WANG Tong, LIU Zijing, ZHAO Pengcheng, XIAO Yingjie   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Speed and Path Planning Optimization of Autonomous Vehicle to Minimize Lap Time in Racing Track

IEEE Access
This study proposes a trajectory optimization method for racing vehicles, aiming to maximize speed and path planning performance by estimating tire friction coefficients.
Young-Jin Roh, Ji-Ung Im, Jong-Hoon Won
doaj   +1 more source