Results 31 to 40 of about 90,070 (198)

Fast B-spline Curve Fitting by L-BFGS

, 2011
We propose a novel method for fitting planar B-spline curves to unorganized data points. In traditional methods, optimization of control points and foot points are performed in two very time-consuming steps in each iteration: 1) control points are ...
Bo, Pengbo, Liu, Yang, Wang, Wenping, Zheng, Wenni   +3 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Complexity in surfaces of densest packings for families of polyhedra

, 2013
Packings of hard polyhedra have been studied for centuries due to their mathematical aesthetic and more recently for their applications in fields such as nanoscience, granular and colloidal matter, and biology.
Chen, Elizabeth R., Damasceno, Pablo F., Engel, Michael, Glotzer, Sharon C., Klotsa, Daphne   +4 more
core   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Viscous regularization and r-adaptive remeshing for finite element analysis of lipid membrane mechanics

, 2007
As two-dimensional fluid shells, lipid bilayer membranes resist bending and stretching but are unable to sustain shear stresses. This property gives membranes the ability to adopt dramatic shape changes. In this paper, a finite element model is developed
Alberts, Ayton, Bacia, Balluffi, Baumgart, Baumgart, Bozic, Božič, Byrd, Canham, Capovilla, Cirak, Cirak, Derényi, Do Carmo, Du, Du, Evans, Evans, Feng, Frey, Fygenson, Gompper, Heinrich, Heinrich, Helfrich, Ho, Hsu, Jaric, Jenkins, Jenkins, Jiang, Jülicher, Jülicher, Kawakatsu, Kraus, Lin Ma, Lipowsky, Nocedal, Noguchi, Noguchi, Powers, Seifert, Seifert, Seifert, Smith, Snapp, Sokolnikoff, Steigmann, Svetina, Svetina, Svetina, Taniguchi, Taniguchi, Toledano, Wang, Wiese, William S. Klug, Wintz, Zhu   +59 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Optimization in Differentiable Manifolds in Order to Determine the Method of Construction of Prehistoric Wall-Paintings

, 2011
In this paper a general methodology is introduced for the determination of potential prototype curves used for the drawing of prehistoric wall-paintings.
Arabadjis, Dimitris, Exarhos, Michalis, Panagopoulos, Michalis, Papaodysseus, Constantin, Papazoglou-Manioudaki, Lena, Rousopoulos, Panayiotis   +5 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Shape from Shading through Shape Evolution

, 2017
In this paper, we address the shape-from-shading problem by training deep networks with synthetic images. Unlike conventional approaches that combine deep learning and synthetic imagery, we propose an approach that does not need any external shape ...
Deng, Jia, Yang, Dawei
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source