Results 41 to 50 of about 1,948,122 (285)
Euler’s optimal profile problem [PDF]
Calculus of Variations and Partial Differential Equations, 2020 We study an old variational problem formulated by Euler as Proposition 53 of his `Scientia Navalis' by means of the direct method of the calculus of variations. Precisely, through relaxation arguments, we prove the existence of minimizers. We fully investigate the analytical structure of the minimizers in dependence of the geometric parameters and we ...
Maddalena, Francesco +2 more
openaire +5 more sources
A variational framework for flow optimization using semi-norm constraints [PDF]
, 2012 When considering a general system of equations describing the space-time evolution (flow) of one or several variables, the problem of the optimization over a finite period of time of a measure of the state variable at the final time is a problem of great
C. P. Caulfield +4 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Mathematical and Computational Applications, 2018 We consider a general problem of optimal allocation of limited resources in a wireless telecommunication network. The network users are divided into several different groups (or classes), which correspond to different levels of service.
Igor Konnov +2 more
doaj +1 more source
Path optimization method for the sign problem
, 2017 We propose a path optimization method (POM) to evade the sign problem in the Monte-Carlo calculations for complex actions. Among many approaches to the sign problem, the Lefschetz-thimble path-integral method and the complex Langevin method are promising
Kashiwa, Kouji +2 more
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Applications of Bee Colony Optimization [PDF]
, 2013 Many computationally difficult problems are attacked using non-exact algorithms, such as approximation algorithms and heuristics. This thesis investigates an ex- ample of the latter, Bee Colony Optimization, on both an established optimization problem in
CHALK, AIDAN BERNARD GERARD
core
Solving ill-posed bilevel programs [PDF]
, 2016 This paper deals with ill-posed bilevel programs, i.e., problems admitting multiple lower-level solutions for some upper-level parameters. Many publications have been devoted to the standard optimistic case of this problem, where the difficulty is ...
AG Mersha +43 more
core +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source