Results 61 to 70 of about 588,921 (316)
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
Fractional optimization problems
Известия Иркутского государственного университета: Серия "Математика", 2014 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
ENKHBAT RENTSEN, BAYARTUGS TAMJAV
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Intelligent Tutoring Systems for Adult Learning in STEM Disciplines
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley +1 more source
Modification of the random search method
Технічна інженерія, 2020 The paper considers linear programming problems with Boolean variables. This is a part of mathematical programming focused on solving practical optimization problems, which could be solved and correctly described with a mathematical model of the problem ...
S.I. Yaremchuk, O.A. Shupikov
doaj +1 more source
IEEE Access, 2022 In this paper, a heuristic scheme based on the hybridization of Bernstein Polynomials (BPs) and nature-inspired optimization techniques is presented to achieve the numerical solution of Nonlinear Optimal Control Problems (NOCPs) efficiently. The solution
Ghulam Fareed Laghari +5 more
doaj +1 more source
Pathwise Optimization for Optimal Stopping Problems [PDF]
Management Science, 2012 We introduce the pathwise optimization (PO) method, a new convex optimization procedure to produce upper and lower bounds on the optimal value (the “price”) of a high-dimensional optimal stopping problem. The PO method builds on a dual characterization of optimal stopping problems as optimization problems over the space of martingales, which we dub ...
Vijay V. Desai +2 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source
Numerical solution of the age structure optimization problem for basic types of power plants [PDF]
Yugoslav Journal of Operations Research, 2019 Our paper addresses an integral model of the large electric power system optimal development. The model takes into account the age structure of the main equipment, which is divided into several types regarding its technical characteristics.
Markova Evgeniia V., Sidler Inna V.
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Chases and escapes, and optimization problems [PDF]
Artificial Life and Robotics, 2015 We propose a new approach for solving combinatorial optimization problem by utilizing the mechanism of chases and escapes, which has a long history in mathematics. In addition to the well-used steepest descent and neighboring search, we perform a chase and escape game on the "landscape" of the cost function. We have created a concrete algorithm for the
Toru Ohira +2 more
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