Results 21 to 30 of about 20,409,856 (229)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
An evaluation of BMX6 for Community Wireless Networks [PDF]
, 2012 Nowadays, a growing number of communities of citizens build, operate and own open IP-based community wire- less networks with thousands of low capacity nodes actively participating in routing the data traffic.
Navarro, Leandro +7 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Manet As A Solution Network Implementation In The Provision Of Services In Regional Disaster Information [PDF]
The concept of a wireless network is a packet radio network that uses as its transmission medium. Wireless network is based on the configuration mode is divided into Infrastructure and Ad-Hoc.
Anang , Sularsa +2 more
core +1 more source
Let the Tree Bloom: Scalable Opportunistic Routing with ORPL [PDF]
, 2013 Routing in battery-operated wireless networks is challenging, posing a tradeoff between energy and latency. Previous work has shown that opportunistic routing can achieve low-latency data collection in duty-cycled networks.
Voigt, Thiemo, +7 more
core +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Macro-routing: a new hierarchical routing protocol [PDF]
, 2004 In a continually evolving Internet, tools such as quality of service routing must be used in order to accommodate user demands. QoS routing raises scalability issues within very large networks, which can he avoided by using hierarchical routing ...
Martin Collier +5 more
core +2 more sources