Results 51 to 60 of about 2,133 (299)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Germany versus the United States: Monetary Dominance in the Eurozone
Economies, 2016 This study inspects if there is greater convergence with Germany amongst the Eurozone founding members and if their relations with the hegemonic economy have been more symmetrical after “euroization”.
Chee-Heong Quah
doaj +1 more source
Competitiveness of the economy and the crisis of the European Monetary Union [PDF]
Bankarstvo, 2014 The crisis in the European Monetary Union revealed the internal weaknesses of its functioning. The evolution of the EMU was not accompanied by appropriate structural transformations.
Grbić Vladimir, Todić Dragoljub
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
THE APPLICATION OF OPTIMUM CURRENCY AREA CRITERIA TO EUROPEAN MONETARY UNION [PDF]
Challenges of the Knowledge Society, 2011 Debt crisis in several Member States of the euro area has reopened discussions regarding the sustainability of European Monetary Union. Adoption of the single currency has proven to be more costly for the economies which are structurally divergent from ...
CRISTIAN SOCOL +2 more
doaj
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
OCA Indexes and Convergence Process in Europe
Scientific Annals of Economics and Business, 2017 This paper evaluates the European monetary convergence for period 2001 and 2013. The main purpose of this contribution is the estimation of the so-called OCA index, which indicates the proximity of two economic areas.
Frydrych Jakub, Burian Stanislav
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The Monetary Integration of the New Member States before the Euro Area Debt Crisis [PDF]
Managing Global Transitions, 2013 This paper analyzes the process of monetary integration of the New Member States in the European Union till the beginning of the Euro Area debt crisis. The focus of investigation is on the nominal convergence (the fulfillment of the Maastricht criteria ...
Ivan Todorov
doaj