Results 61 to 70 of about 6,643,053 (305)

An Optimum-Currency-Area Odyssey [PDF]

open access: yes
The theory of optimum-currency-areas was conceived and developed in three highly influential papers, written by Mundell (1961), McKinnon (1963) and Kenen (1969).
Harris Dellas, George S.Tavlas
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ANALYSIS OF ECONOMIC SHOCKS AFFECTING EURO AREA [PDF]

open access: yesChallenges of the Knowledge Society, 2011
The objective of this study is to explain the causes of economic shocks that are manifested in the euro area countries and to examine the possibilities of their adjustment in the context of a common monetary policy.
MARIUS-CORNELIU MARINAS
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Adopting the Euro: Costs or Benefits? [PDF]

open access: yesTheoretical and Applied Economics, 2007
This paper evaluates the present estate of euro implementation in Monetary and Economic Union (EMU). The Romanian admittance in EU at January 2007 increases interest to study the transmission and coordination mechanisms, related to mix common monetary ...
Cristian Socol, Aura Socol
doaj   +1 more source

Optimum Currency Area Indices - How Close is the Czech Republic to the Eurozone? [PDF]

open access: yes
In this paper we provide a survey of the optimum currency area theory, estimate the degree of the explanatory power of the optimum currency area criteria, and also calculate the optimum currency area index in the case of the Czech Republic.
Lubos Komarek   +2 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Optimum Currency Areas Under Inflation Targeting

open access: yesOpen Economies Review, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Røisland, Øistein, Torvik, Ragnar
openaire   +4 more sources

Is Mercosur an optimum currency area? [PDF]

open access: yes
We find that generalized purchasing power parity does not hold for Mercosur, and thus that the South American trade group does not constitute an optimum currency area. We also find that the role of the United States cannot be neglected in the region, and
Stocco, Leandro   +2 more
core  

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