Results 111 to 120 of about 208,234 (267)
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Optimum Safe Hydraulic Design of Culverts
Journal of Engineering and Sustainable Development, 2008 This research aims at obtaining the "Optimum safe hydraulic design of culverts", taking into consideration the cost of excavation, bedding, material, compacted fill, hunches, protection works, and additionally involved head loss.Because of numerous ...
Abdul-Hadi A. Al-Delewy +2 more
doaj
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Optimum Design of Cylindrical Worm Drive
Jixie chuandong, 2016 Taking a cylindrical worm drive mechanism as the research object,the minimizing the volume of worm gear as objective function,the limit of the worm gear tooth surface contact strength,worm stiffness,number of worm threads,worm gear module and worm ...
Wang Yuandong
doaj
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
OPTIMUM HYDRAULIC DESIGN FOR INVERTED SIPHON
Al-Qadisiyah Journal for Engineering Science, 2008 In this research, optimum hydraulic design for siphon has been studied depending on the method of optimization (Modified Hooke and Jeeves) with some modifications. Some modifications on this method have done.
Thulfikar Razzak Al- Husseini
doaj
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Optimum Designs for Optimum Mixtures: An Informative Review
International Journal of Statistical SciencesIn a mixture experiment, the measured response is assumed to depend only on the relative proportions of ingredients or components present in the mixture. Scheffe´ (1958) first systematically considered this problem, and introduced different models and suitable designs.
openaire +1 more source