Results 91 to 100 of about 200,906 (266)
Optimum design of reference points distribution in three-dimensional reconstruction of dental model in intercuspal position. [PDF]
BMC Oral Health, 2021 Wu Y +5 more
europepmc +1 more source
The Annals of Mathematical Statistics, 1959 Suppose we are given $N$ objects to be weighed in $N$ weighings with a chemical balance having no bias. Let $x_{ij} = 1$ if the $j$th object is placed in the left pan in the $i$th weighing, $= -1$ if the $j$th object is placed in the right pan in the $i$th weighing, $= 0$ if the $j$th object is not weighed in the $i$th weighing. The $N$th order matrix $
openaire +3 more sources
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Process parameters optimization in pressure vibration injection molding
Nihon Kikai Gakkai ronbunshuPlastic injection molding (PIM) is a major manufacturing technology to produce plastic products for high product quality and high productivity. The process parameters such as the melt temperature, the packing pressure and the cooling time affect the ...
Kenta YAMAYA +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Optimum Designs for Polynomial Extrapolation
The Annals of Mathematical Statistics, 1965 A solution is given to the problem of where to choose $k + 1$ points and what weights to assign them in order to obtain the minimum variance of what may be called an interior extrapolated value of a polynomial of degree $k$. It is assumed that observations can be taken in the interval $\lbrack -1, 1\rbrack$, except for a subinterval $(\alpha, \beta ...
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source