Results 81 to 90 of about 200,906 (266)

Optimum design of B-series marine propellers

Alexandria Engineering Journal, 2011
The choice of an optimum marine propeller is one of the most important problems in naval architecture. This problem can be handled using the propeller series diagrams or regression polynomials.
M.M. Gaafary, H.S. El-Kilani, M.M. Moustafa   +2 more
doaj   +1 more source

CFD Analysis and Optimum Design for a Centrifugal Pump Using an Effectively Artificial Intelligent Algorithm. [PDF]

Micromachines (Basel), 2022
Wang CN, Yang FC, Nguyen VTT, Vo NTM.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

OptDesign: Identifying Optimum Design Strategies in Strain Engineering for Biochemical Production. [PDF]

ACS Synth Biol, 2022
Jiang S, Otero-Muras I, Banga JR, Wang Y, Kaiser M, Krasnogor N.   +5 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Optimum Design of a Composite Optical Receiver by Taguchi and Fuzzy Logic Methods. [PDF]

Micromachines (Basel), 2021
Wang N, Peng X, Kong L.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Tapped-inductor bi-directional Cuk converter with high step-up/down conversion ratio and its optimum design. [PDF]

Sci Rep, 2022
Chen H, Lin WM, Liu WR, He W.
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Design and fabrication of an automotive frame model leveraging anisotropic topology optimization and tailored fiber placement

Mechanical Engineering Journal
This paper presents a case study of the design, fabrication, and evaluation of an automotive rear-frame model made of variable axial composites (VAC), using a tailored fiber placement (TFP) technique.
Yoshihiro IWANO, Atsushi WADA, Ryohei TAKAYAMA, Masaaki TANAKA, Yuqing ZHOU, Isao OHASHI, Katsuharu YOSHIKAWA, Atsushi KAWAMOTO, Tsuyoshi NOMURA   +8 more
doaj   +1 more source