Results 51 to 60 of about 1,140,649 (309)

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson   +20 more
wiley   +1 more source

Solution to shape design problems of unsteady forced heat-convection fields

open access: yesNihon Kikai Gakkai ronbunshu, 2017
This paper presents numerical solution to two shape design problems of unsteady forced heat-convection fields to control temperature to a prescribed distribution.
Eiji KATAMINE, Naoya OKADA
doaj   +1 more source

Outcomes and Surgical Management of Malignant Rhabdoid Tumor of the Kidney: A Report From the Pediatric Surgical Oncology Research Collaborative

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Malignant rhabdoid tumor of the kidney (MRTK) is a rare, aggressive tumor seen in young children. The optimal timing of resection for locally advanced tumors is not well‐defined. The purpose of this study is to evaluate modern oncologic outcomes and the impact of surgical timing. Methods A multicenter retrospective review was performed
Hannah N. Rinehardt   +76 more
wiley   +1 more source

The Usage of the Harmony Search Algorithm for the Optimal Design Problem of Reinforced Concrete Retaining Walls

open access: yesApplied Sciences, 2021
In this paper, the Harmony Search (HS) algorithm is utilized to perform single and multivariate parametric studies to acquire the optimization of both size and cost of reinforced concrete (RC) retaining walls embedded in pure frictional soils.
Zülal Akbay Arama   +4 more
doaj   +1 more source

Optimum design of composite prestressed concrete girder railway bridges [PDF]

open access: yes, 2012
This paper deals with the formulation of design optimisation of pretsressed concrete bridges. The bridge is of a slab-on-girder type, hence modeled as an equivalent orthotropic plate.
Al-Nuaimi, A, Mohammad, F, Mohammed, S
core  

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa   +3 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Theoretical Analysis and Optimum Design of High Speed Air Film Thrust Bearings

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2007
Hydrodynamic air film thrust bearings are widely used for very high speed, lightly loaded rotating machinery such as gas expander, compressor, gyroscope and business machines, etc. In the design of hydrodynamic air film thrust bearings, it is of cardinal
Hiromu HASHIMOTO   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Vibrations Suppression Control of Image Transfer Belt System with Flywheel or Dynamic Vibration Absorber

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2013
The purpose of this study was to investigate vibrations suppression control methods of image transfer belt system which is widely applied in image formation procedure of printers and copy machines. The study focused on vibrations caused by loading torque
Jie YU   +3 more
doaj   +1 more source

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