Results 51 to 60 of about 200,906 (266)

DECOMPOSITION OF OPTIMUM DESIGN PROBLEMS

open access: yesStudia Universitatis Moldaviae: Stiinte Umanistice, 2008
În lucrare sunt prezentate rezultalele rezolvării problemei de optimizare a forţei critice de pierdere a stabilităţii placii ortotropice prin alegerea raţională a unghiului de ortotropie ϕ( x, y ).
USM ADMIN
doaj  

Optimal Design of RC Frames using a Modified Hybrid PSOGSA Algorithm

open access: yesArchives of Civil Engineering, 2017
The present study has been taken up to emphasize the role of the hybridization process for optimizing a given reinforced concrete (RC) frame. Although various primary techniques have been hybrid in the past with varying degree of success, the effect of ...
Chutani Sonia, Singh Jagbir
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multi-objective optimization in plastic injection molding with injection and packing time

open access: yesNihon Kikai Gakkai ronbunshu, 2015
Plastic injection molding (PIM) is one of the most important manufacturing processes for producing plastic products. The process parameters in the PIM, such as mold temperature, melt temperature, and injection pressure affect the product quality and the ...
Shinji NATSUME, Satoshi KITAYAMA
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Study on the Optimum Design of a Ground Heat Pump System Using Optimization Algorithms

open access: yesEnergies, 2019
Geothermal energy has attracted attention as a high-efficiency energy source that can be used year-round, but it has a relatively higher initial investment cost.
Hyeongjin Moon, Hongkyo Kim, Yujin Nam
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Electromagnet Weight Reduction in a Magnetic Levitation System for Contactless Delivery Applications

open access: yesSensors, 2010
This paper presents an optimum design of a lightweight vehicle levitation electromagnet, which also provides a passive guide force in a magnetic levitation system for contactless delivery applications. The split alignment of C-shaped electromagnets about
Ki-Chang Lee   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

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