Results 81 to 90 of about 1,140,649 (309)
Design of structures for optimum geometry [PDF]
A method is presented for configuration optimization of finite element structures, given a reasonable initial geometry. The objective is to minimize weight or cost. Design variables include geometric as well as member sizing parameters.
Vanderplaats, G. N.
core +1 more source
Exploration versus Exploitation Using Kriging Surrogate Modelling in Electromagnetic Design [PDF]
, 2011 This paper discusses the use of kriging surrogate modelling in multiobjective design optimisation in electromagnetics. The importance of achieving appropriate balance between exploration and exploitation is emphasised when searching for the global ...
Jan K. Sykulski +3 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
An approach to optimum subsonic inlet design [PDF]
Inlet operating requirements are compared with estimated inlet separation characteristics to identify the most critical inlet operating condition. This critical condition is taken to be the design point and is defined by the values of inlet mass flow ...
Diedrich, J. H. +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Optimum Design of Trapezoidal Combined Footings
Tikrit Journal of Engineering Sciences, 2007 This study is an application of one of the non-linear programming methods ; Hooke & Jeeves method to the structural design of the trapezoidal combined footings , considering the total cost of the footing as an objective function .
Eman M. Farhan Al-Douri
doaj +1 more source
Optimum structural design with static aeroelastic constraints [PDF]
The static aeroelastic performance characteristics, divergence velocity, control effectiveness and lift effectiveness are considered in obtaining an optimum weight structure. A typical swept wing structure is used with upper and lower skins, spar and rib
Bowman, Keith B +2 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Optimum design of steel structures 2013
Engineering Structures and Technologies, 2014 "Optimum design of steel structures 2013" review."Engineering Structures and Technologies, 6(1), pp ...
Audronis Kazimieras Kvedaras +1 more
doaj +1 more source