Results 201 to 210 of about 31,983 (250)

Evolution of the rate, molecular spectrum, and fitness effects of mutation under minimal selection in Caenorhabditis elegans. [PDF]

Genetics
Saber S, Rifat MMI, Rahimi F, Snyder M, Singh A, Eickwort B, Newhall Y, Rajaei M, Saxena AS, Tanny RE, Katju V, Andersen EC, Zhou J, Baer CF.   +13 more
europepmc   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Atmospheric room-temperature plasma mutagenesis and heterologous expression of dextranase in Aspergillus niger. [PDF]

AMB Express
Huang X, Yang L, Zhang W, Yang D, Guo H, Zhang B, Jiang M, Pan L.   +7 more
europepmc   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Dynamic-opposite learning enhanced meta-heuristic approach for solving multiple industrial optimization problems. [PDF]

Sci Rep
Wu H, Li L, Wang G, Yang Z, Shi B.
europepmc   +1 more source

Immobilized Wild-Type and Mutant L‑Alanine Dehydrogenase from <i>Thermus thermophilus</i> Coupled with Formate Dehydrogenase for Asymmetric Synthesis of Noncanonical Amino Acids. [PDF]

ACS Omega
Demir Ğ, Yildirim D, Binay B.
europepmc   +1 more source

Structure-Based Design and Mechanistic Insight for Enhanced Catalytic Activity of Aldo/Keto Reductase AKR13B3 from <i>Devosia</i> A6-243 Toward T-2 Toxin. [PDF]

Toxins (Basel)
Liu J, Chi H, Zhu X, Jiang Q, Lu Z, Zhu P, Lu F.   +6 more
europepmc   +1 more source

Enhancing detection of polygenic adaptation: a comparative study of machine learning and statistical approaches using simulated evolve-and-resequence data. [PDF]

BMC Genomics
Caliendo C, Gerber S, Pfenninger M.
europepmc   +1 more source

Isosteric Engineering of Enzymes: Overcoming Activity-Stability Trade-Offs by Site-Selective CH → N Substitutions. [PDF]

Angew Chem Int Ed Engl
Abdelkader EH, Qianzhu H, Otting G, Huber T.   +3 more
europepmc   +1 more source

Cross-Model Uncertainty-Aware Minimal Editing of Cis-Regulatory Elements for Cell-Type-Selective Design. [PDF]

Genes (Basel)
Xia A, Wang C, Xia Y.
europepmc   +1 more source