Results 51 to 60 of about 13,905,601 (245)

Level of adherence and predictors of adherence to the Option B+ PMTCT programme in Tigray, northern Ethiopia

International Journal of Infectious Diseases, 2015
Objective: The aim of this study was to determine the level of adherence to Option B+ PMTCT drugs and factors associated with adherence among HIV-positive pregnant women in public hospitals of Tigray, northern Ethiopia.
Haftamu Ebuy, Henock Yebyo, Mussie Alemayehu   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

ART Attrition across Health Facilities Implementing Option B+ in Haiti

Journal of the International Association of Providers of AIDS Care, 2018
Background: Describing factors related to high attrition is important in order to improve the implementation of the Option B+ strategy in Haiti. Methods: We conducted a retrospective cohort study to describe the variability of antiretroviral therapy (ART)
Martine Pamphile Myrtil MD, MPH, Nancy Puttkammer MPH, PhD, Stephen Gloyd MD, MPH, Julia Robinson MSW, MPH, Krista Yuhas MS, Jean Wysler Domercant MD, MPH, Jean Guy Honoré MD, Kesner Francois MD   +7 more
doaj   +1 more source

Using a composite adherence tool to assess ART response and risk factors of poor adherence in pregnant and breastfeeding HIV-positive Cameroonian women at 6 and 12 months after initiating option B+

BMC Pregnancy and Childbirth, 2018
Background Antiretroviral therapy (ART) adherence in preventing HIV mother-to-child transmission in association with virological suppression and risk factors of low adherence in the Cameroon’s Option B+ programme are poorly understood.
Pascal N. Atanga, Harrison T. Ndetan, Peter N. Fon, Henry D. Meriki, Tih P. Muffih, Eric A. Achidi, Michael Hoelscher, Arne Kroidl   +7 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Health Provider Perspectives of Health Facility Preparedness and Organization in Implementation of Option B+ among Pregnant and Lactating Women in Central Uganda: A Qualitative Study

Journal of the International Association of Providers of AIDS Care, 2019
Introduction: Uganda adopted Option B+ for prevention of mother-to-child transmission (PMTCT) of HIV in 2012. However, there is limited data on preparedness and organization of Option B+ services.
Aggrey David Mukose MBChB, MS, Hilde Bastiaens MD, PhD, Esther Buregyeya MBChB, MPhil, PhD, Rose Naigino BST/B, MHSR, Fredrick Makumbi MS, MHS, PhD, Joshua Musinguzi MBChB, MPH, Jean-Pierre Van geertruyden MD, PhD, Rhoda K. Wanyenze MBChB, MPH, PhD   +7 more
doaj   +1 more source

Pursuing ethical coherence in the prevention of vertical transmission of HIV: justice and injustice in Option B+

Journal of Virus Eradication, 2017
Improved prevention of vertical transmission of HIV is an essential part of the global response to HIV. The Option B+ strategy took the extraordinary step of treating many non-pregnant women living with HIV (those with CD4 cell counts >350 cells/mm3) in ...
Nathan Hodson, Susan Bewley
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source