Results 121 to 130 of about 43,018 (315)

Optogenetics for Retinal Disorders

Journal of Ophthalmic & Vision Research, 2014
Optogenetics is the use of genetic methods combined with optical technology to achieve gain or loss of function within neuronal circuits. The field of optogenetics has been rapidly expanding in efforts to restore visual function to blinding diseases such
Bradley S Henriksen, Robert E Marc, Paul S Bernstein   +2 more
doaj   +1 more source

Single‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region

Advanced Science, EarlyView.
Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen, Shuyang Yao, Sihui Cheng, Jiayi Tian, Ang Li, Yusen Yan, Xiang Zhang, Yuanjing Liu, Yumeng Wang, Qichen Cao, Chenglin Miao   +10 more
wiley   +1 more source

The status and challenges of optogenetic tools for precise spatiotemporal control of RNA metabolism and function

Clinical and Translational Medicine, 2022
Renmei Liu, Mengyue Fang, Xianjun Chen, Yi Yang   +3 more
doaj   +1 more source

Acute silencing of hippocampal CA3 reveals a dominant role in place field responses. [PDF]

, 2019
Neurons in hippocampal output area CA1 are thought to exhibit redundancy across cortical and hippocampal inputs. Here we show instead that acute silencing of CA3 terminals drastically reduces place field responses for many CA1 neurons, while a smaller ...
Davoudi, Heydar, Foster, David J
core  

The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep

Advanced Science, EarlyView.
Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller, Anton Filipchuk, Sophie Bagur, Brice Bathellier   +3 more
wiley   +1 more source

Optogenetic therapeutic strategies for diabetes mellitus

Journal of Diabetes
Diabetes mellitus (DM) is a common chronic disease affecting humans globally. It is characterized by abnormally elevated blood glucose levels due to the failure of insulin production or reduction of insulin sensitivity and functionality.
Xin Deng, Dandan Peng, Yuanfa Yao, Ke Huang, Jinling Wang, Zhihao Ma, Junfen Fu, Yingke Xu   +7 more
doaj   +1 more source

Optogenetics and its application in neural degeneration and regeneration

Neural Regeneration Research, 2017
Neural degeneration and regeneration are important topics in neurological diseases. There are limited options for therapeutic interventions in neurological diseases that provide simultaneous spatial and temporal control of neurons.
Josue D Ordaz, Wei Wu, Xiao-Ming Xu
doaj   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Functional ultrasound imaging of the spreading activity following optogenetic stimulation of the rat visual cortex [PDF]

, 2021
Matthieu Provansal, Guillaume Labernède, Corentin Joffrois, A. Rizkallah, Ruben Goulet, Manon Valet, W. Deschamps, Ulisse Ferrari, Antoine Chaffiol, Deniz Dalkara, José‐Alain Sahel, Mickaël Tanter, Serge Picaud, Grégory Gauvain, Fabrice Arcizet   +14 more
openalex   +1 more source