Results 121 to 130 of about 55,224 (387)
Biological and Mechanical Limitations for Chronic Fast‐Scan Cyclic Voltammetry Sensor Design
Advanced Materials Technologies, EarlyView.Real‐time detection of neurochemicals has demonstrated value in the field of neuroscience. However, current methods have limitations for use in the chronic setting, which is often the ideal environment for research. This article discusses these limitations, as well as technologies that have been developed to overcome them, and provides recommendations ...
Mason L. Perillo +6 more
wiley +1 more source
Suppression of the Spectral Cross Talk of Optogenetic Switching by Stimulated Depletion Quenching. Theoretical Analysis [PDF]
arXiv, 2018 Optogenetics is a rapidly growing field of biotechnology, potentially allowing a deeper understanding and control of complex biological networks. The major challenge is the multiplexed control of several optogenetic components in the presence of significant spectral cross talk.
arxiv
Optogenetically Induced Spatiotemporal Gamma Oscillations in Visual Cortex [PDF]
arXiv, 2021 It has been hypothesized that Gamma cortical oscillations play important roles in numerous cognitive processes and may involve psychiatric conditions including anxiety, schizophrenia, and autism. Gamma rhythms are commonly observed in many brain regions during both waking and sleep states, yet their functions and mechanisms remain a matter of debate ...
arxiv
Machine learning-guided channelrhodopsin engineering enables minimally-invasive optogenetics
Nature Methods, 2019 We engineered light-gated channelrhodopsins (ChRs) whose current strength and light sensitivity enable minimally invasive neuronal circuit interrogation. Current ChR tools applied to the mammalian brain require intracranial surgery for transgene delivery
C. N. Bedbrook +5 more
semanticscholar +1 more source
The Dawning of Primate Optogenetics [PDF]
Neuron, 2009 In this issue of Neuron, Han and colleagues bring optogenetic methods into use in nonhuman primates by demonstrating the feasibility of achieving cell-type-specific photoactivation of macaque neocortical neurons. The use of optogenetic approaches in nonhuman primates promises to revolutionize our understanding of the neural circuitry that mediates ...
Tamara Berdyyeva, John V. Reynolds
openaire +3 more sources
Curvy surface conformal ultra-thin transfer printed Si optoelectronic penetrating microprobe arrays [PDF]
, 2018 Penetrating neural probe arrays are powerful bio-integrated devices for studying basic neuroscience and applied neurophysiology, underlying neurological disorders, and understanding and regulating animal and human behavior.
Li, Yanbin +4 more
core +2 more sources
Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease
Advanced Therapeutics, EarlyView.An upconversion‐based wireless optogenetic strategy enables an all‐optical deep brain modulation solution for treating Parkinson's disease in rodent animals without using electronics or any tethered cables, providing experimental evidence supporting a therapeutic mechanism of STN‐DBS by disruption of anterograde signal transmission along the indirect ...
Wenchong Zhang +13 more
wiley +1 more source
A System-on-Chip for Closed-loop Optogenetic Sleep Modulation [PDF]
arXiv, 2021 Stimulation of target neuronal populations using optogenetic techniques during specific sleep stages has begun to elucidate the mechanisms and effects of sleep. To conduct closed-loop optogenetic sleep studies in untethered animals, we designed a fully integrated, low-power system-on-chip (SoC) for real-time sleep stage classification and stage ...
arxiv
Medial Ganglionic Eminence Progenitors Transplanted into Hippocampus Integrate in a Functional and Subtype-Appropriate Manner. [PDF]
, 2017 Medial ganglionic eminence (MGE) transplantation rescues disease phenotypes in various preclinical models with interneuron deficiency or dysfunction, including epilepsy.
Baraban, Scott C, Hsieh, Jui-Yi
core +1 more source
Advanced Science, EarlyView.Selective lesioning of SuM glutamatergic neurons promoted the induction of and delayed emergence from sevoflurane anesthesia and increased sevoflurane sensitivity. Optogenetic stimulation of SuM glutamatergic neurons or the SuM‐MS projection promoted behavioral arousal and cortical activation under steady‐state sevoflurane anesthesia and reduced the ...
Jiayan Li +8 more
wiley +1 more source