Results 81 to 90 of about 6,988 (158)

Alcohol exposure promotes cell communication network 1 cleavage in esophageal adenocarcinoma cells exclusively

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
An illustration shows how cell communication network 1 (CCN1) is involved in the normal esophagus, esophageal squamous cell carcinoma (ESCC), and esophageal adenocarcinoma (EAC) after alcohol exposure. Alcohol exposure upregulates CCN1 expression in the esophageal epithelium, with or without esophageal cancer. In normal individuals, CCN1 repairs tissue
Wula Aladan, Baoxin Chi, Zhiheng Chang, Mizhu Wang, Tong Dang, Xianmei Meng, Jianyuan Chai   +6 more
wiley   +1 more source

Trabajo y sociedad en arqueología. Producciones y relaciones versus orígenes y desigualdades

Revista Atlántica-Mediterránea de Prehistoria y Arqueología Social, 2004
Castro, Pedro V., Escoriza, Trinidad
openaire   +2 more sources

Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights

The Journal of Pathology, Volume 270, Issue 1, Page 114-128, September 2026.
Abstract Tumor border configuration influences colorectal cancer (CRC) prognosis, yet its molecular determinants remain unclear and existing assessment criteria have faced challenges with reproducibility. We introduce the Tumor Invasive Border Index (TIBI), a novel and reproducible method that quantifies the proportion of tumor stroma and adipose ...
Akseli Kehusmaa, Jouni Härkönen, Huayi Li, Päivi Sirniö, Ville K Äijälä, Henna Karjalainen, Meeri Kastinen, Vilja V Tapiainen, Tuomo Mantere, Vesa‐Matti Pohjanen, Hanna Elomaa, Onni Sirkiä, Nicolas Pasquier, Maarit Ahtiainen, Olli Helminen, Erkki‐Ville Wirta, Taneli T Mattila, Outi Lindgren, Janette Savela, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Toni T Seppälä, Jan Böhm, Jukka‐Pekka Mecklin, Markus J Mäkinen, Anne Tuomisto, Johanna Ivaska, Juha P Väyrynen   +29 more
wiley   +1 more source

Cronotopía en la región más transparente de Carlos Fuentes

Cuadernos de Lingüística Hispánica, 2007
El artículo intitulado "Cronotopía en La región más transparente de Carlos Fuentes" muestra un recorrido de la noción de cronotopía en la Historia universal de la novela, basado en la teoría de Mijael Bajtin.
GILMA BUITRAGO DE MUÑOZ, MARTHA PARDO SEGURA   +1 more
doaj  

‘I'm Dead!’: Action, Homicide and Denied Catharsis in Early Modern Spanish Drama

Renaissance Studies, Volume 40, Issue 4, Page 570-588, September 2026.
Abstract In early modern Spanish drama, the expression ‘¡Muerto soy!’ (‘I'm dead!’) is commonly used to indicate a literal death or to figuratively express a character's extreme fear or passion. Recent studies, even one collection published under the title of ‘¡Muerto soy!’, have paid scant attention to the phrase in context, a serious omission when ...
Ted Bergman
wiley   +1 more source

Aproximación a los orígenes de la preceptiva sobre escritura periodística (1840-1940)

Communication & Society (Formerly Comunicación y Sociedad), 1997
El estudio de esta parcela del periodismo, más allá de la mera curiosidad histórica, cobra en nuestros días un interés añadido. Y ello por la aparición de distintas tentativas procedentes de ámbitos académicos y profesionales que pretenden mover los ...
Ramón Salaverría
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, Volume 20, Issue 8, Page 1913-1932, August 2026.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

El Anuario de Historia Social y de la Cultura: sus orígenes y desarrollo

Anuario Colombiano de Historia Social y de la Cultura, 2003
Al iniciarse la década de los sesentas, la carrera de Filosofía y Letras de la Universidad Nacional daba a los estudiantes la posibilidad de escoger, a partir del quinto semestre, una intensificación de los estudios en dirección a la filosofía o hacia la
Jaime Jaramillo Uribe
doaj   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, Volume 20, Issue 8, Page 2085-2101, August 2026.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, Volume 16, Issue 8, Page 1563-1592, August 2026.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source