Results 101 to 110 of about 5,414,777 (320)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A clinical diagnosis of oral leukoplakia : a guide for dentists [PDF]

, 2017
In view of the many white or predominantly white lesions of the oral mucosa it is a challenge for dentists to clinically identify a leukoplakia, being a potentially (pre)malignant lesion.
Carrard, V.C., Waal, Isaäc Van der, van der Waal, I., van der Waal, Isaäc, VC Carrard, I van der Waal, Carrard, Vinicius C.   +6 more
core   +2 more sources

Limited Şirketlerde Yönetim Yetkisinin Devri ve Yetki Devri Halinde Üst Gözetim Yükümlülüğü

Sakarya Üniversitesi Hukuk Fakültesi Dergisi/Sakarya Hukuk Dergisi
Limited şirketlerde yönetim görevi müdürler kurulu aracılığıyla gerçekleştirilmektedir. Büyüyen ve gelişen ticari hayatta limited şirketlerde de yönetimde profesyonelleşme ihtiyacı doğmuştur.
Bahar Oral
doaj   +1 more source

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

Pharmaceutics, 2019
Routes of drug administration and the corresponding physicochemical characteristics of a given route play significant roles in therapeutic efficacy and short term/long term biological effects.
B. Homayun, Xueting Lin, Hyo-Jick Choi
semanticscholar   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

MEVLÂN’NIN HOCASI SEYYİD BURHANEDDİN VE BAZI İTİKÂDÎ KELÂMÎ GÖRÜŞLERİNİN DEĞERLENDİRİLMESİ

Bozok Üniversitesi İlahiyat Fakültesi Dergisi, 2016
Kelâm İlminin esas gâyelerinden biri ve en önemlisi; kişide sağlam bir inanç oluşturmak ve bu inancı, bir takım vaki şüphelerle sarsıntıya uğramayacak şekilde muhafaza, bu yolda Kurân ve sünnet ışığında çeşitli metod ve teknikleri müslümanlara sunma ...
Osman Oral
doaj  

Effect of using gasoline and gasoline-ethanol fuel mixture on performance and emissions in a hydrogen generator supported SI engine

Case Studies in Thermal Engineering
The study presents a gasoline engine's performance and emissions results using ethanol and a hydrogen-oxygen mixture as supplementary fuels. The experiment was carried out utilizing a SI engine (single-cylinder), encompassing six different speeds (1500 ...
Faruk Oral
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source