Results 81 to 90 of about 5,414,777 (320)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Oral health-related quality of life after dental treatment in patients with intellectual disability

, 2020
Background: The influence of dental treatment on oral health-related quality of life (OHRQOL) has rarely been evaluated in patients with intellectual disability (ID) through validated questionnaires.
Toledano Valero, Pilar, Coello Suanzes, José Antonio, Rollón Mayordomo, Ángel, Rollón Ugalde, Paula, López Jiménez, Ana María, Herce López, Javier, Montero-Martín, Javier, Infante Cossío, Pedro Antonio   +7 more
core   +1 more source

Oral versus Intravenous Antibiotics for Bone and Joint Infection

New England Journal of Medicine, 2019
BACKGROUND The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication. METHODS
Ho-Kwong Li, I. Rombach, R. Zambellas, S. Walker, M. McNally, B. Atkins, Benjamin A Lipsky, H. Hughes, D. Bose, Michelle Kümin, C. Scarborough, P. Matthews, A. Brent, J. Lomas, R. Gundle, M. Rogers, A. Taylor, B. Angus, I. Byren, A. Berendt, S. Warren, F. Fitzgerald, D. Mack, S. Hopkins, J. Folb, H. Reynolds, E. Moore, J. Marshall, N. Jenkins, C. E. Moran, A. Woodhouse, Samantha Stafford, A. Seaton, C. Vallance, C. Hemsley, K. Bisnauthsing, J. Sandoe, I. Aggarwal, Simon Ellis, Deborah Bunn, R. Sutherland, G. Barlow, C. Cooper, C. Geue, N. McMeekin, A. Briggs, P. Sendi, E. Khatamzas, T. Wangrangsimakul, N. Wong, L. Barrett, A. Alvand, Fraser Old, J. Bostock, J. Paul, G. Cooke, G. Thwaites, P. Bejon, M. Scarborough   +58 more
semanticscholar   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Câbirî’nin İ‘câzu’l-Kur’ân Anlayışının Tahlil ve Tenkidi

Tefsir Araştırmaları Dergisi, 2020
Muhammed Âbid el-Câbirî (1935-2010), son dönemin önemli mütefekkirlerindendir. Fehmü’l-Kur’âni’l-Hakîm isimli üç ciltlik tefsiri ve Kur’an’a dair yazdığı Medhal ile’l-Kur’âni’l-Kerîm adlı eseri, tefsir ilmi açısın-dan Cabiri’nin önemini bir kat daha ...
Hüseyin Oral
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Chemo-radiotherapy induced oral mucositis during IMRT for head and neck cancer: an assessment [PDF]

, 2015
Background: This study is conducted mainly to evaluate the changes in quality and quantity of oral epithelial cells during the course of IMRT. Material and Methods: 30 Patients undergoing chemo-radiotherapy were followed through course of treatment ...
Nagarajan, Karthika
core   +1 more source

Ticaret Kavramı Bağlamında Kur’ân’da Uhrevî Ticaret

Antakiyat, 2021
Cahiliye dönemi toplumu, Allah ile bağlantısını bütünüyle koparmış veya Allah ile ilişkisini sorunlu hâle getirmiş, şirkin ve hurafelerin henüz yozlaştırmadığı saf/katışıksız vahyin ortamından olabildiğince uzaklaşmış, çok azı haricinde dünya hayatı ...
Murat Oral
doaj  

Zonguldak ve Karabük Kentlerindeki Anıt Heykellerde İşçi Temsili

Erdem, 2018
Heykel, sanatçının elindeki malzemeleri belirli bir anlam ifade edebilecek, bir ağırlığa ve kapsama sahip olabilecek üç boyutlu anlatımlar haline dönüştürmesi olarak tarif edilebilir.
Bülent Oral
doaj   +1 more source