Results 41 to 50 of about 1,945,723 (242)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Application of Propophol on the Total Intravenous Anesthesia

open access: yesEurasian Journal of Medicine, 2019
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Uğur Oral
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Câbirî’nin İ‘câzu’l-Kur’ân Anlayışının Tahlil ve Tenkidi

open access: yesTefsir Araştırmaları Dergisi, 2020
Muhammed Âbid el-Câbirî (1935-2010), son dönemin önemli mütefekkirlerindendir. Fehmü’l-Kur’âni’l-Hakîm isimli üç ciltlik tefsiri ve Kur’an’a dair yazdığı Medhal ile’l-Kur’âni’l-Kerîm adlı eseri, tefsir ilmi açısın-dan Cabiri’nin önemini bir kat daha ...
Hüseyin Oral
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Ricâl Tenkidinin Rivayet Pratiklerine Etkisi: Süleyman b. Erkam Özelinde Bir İnceleme

open access: yesMarife Dini Araştırmalar Dergisi
Bu çalışma, muhaddislerin, zayıf râvilerden uzak durulması yönündeki eğitsel müdahalelerinin etkinliğini bir râvi üzerinden değerlendirmektedir. Araştırma kapsamında örnek olarak seçilen râvi, dönemin muhaddisleri tarafından "Biz gençken hocalarımız ...
Mustafa Oral
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Ticaret Kavramı Bağlamında Kur’ân’da Uhrevî Ticaret

open access: yesAntakiyat, 2021
Cahiliye dönemi toplumu, Allah ile bağlantısını bütünüyle koparmış veya Allah ile ilişkisini sorunlu hâle getirmiş, şirkin ve hurafelerin henüz yozlaştırmadığı saf/katışıksız vahyin ortamından olabildiğince uzaklaşmış, çok azı haricinde dünya hayatı ...
Murat Oral
doaj  

Zonguldak ve Karabük Kentlerindeki Anıt Heykellerde İşçi Temsili

open access: yesErdem, 2018
Heykel, sanatçının elindeki malzemeleri belirli bir anlam ifade edebilecek, bir ağırlığa ve kapsama sahip olabilecek üç boyutlu anlatımlar haline dönüştürmesi olarak tarif edilebilir.
Bülent Oral
doaj   +1 more source

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