Results 81 to 90 of about 5,644,882 (290)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Overview: Commodity Checkoff Programs [PDF]

Agricultural and Food Policy,
Anonymous, Capps, Oral, Jr.
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

MUHAMMED ZAHİDܒL-KEVSERΒNİN İSR VE Mİ’RÂC GÖRÜŞÜNÜN KELÂMÎ AÇIDAN DEĞERLENDİRİLMESİ

Bozok Üniversitesi İlahiyat Fakültesi Dergisi, 2016
Kelâm İlminin semiyyat kısmına giren nübüvvet meselesinde Hz. Peygamberin Mescid-i Harâmdan Mescid-i Aksâya, oradan da göğe yaptığı İsrâ ve Mirâc yolculuğu, İslâmda beş vakit namazın farz oluşu ile anılır.
Osman Oral
doaj  

Cathepsins in oral diseases

Journal of Dr. NTR University of Health Sciences, 2019
Cathepsins are a class of globular lysosomal proteases known to be responsible for protein degradation. In addition to proteolysis they have many biological roles such as apoptosis wound healing angiogenesis, proenzymatic activation, bone remodelling and
K Ajay Benarji, K Roja Lakshmi, Hasini Nelakurthi, Pothuraju Haritha, Rudraraju Amrutha   +4 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Bir Bölge Olarak Orta Doğu, Sorunları ve Olası İş Birliği Kazanımları

Dünya Coğrafyası ve Kalkınma Perspektifi Dergisi
Türk dış politikasının tarihsel seyri incelendiğinde geçmişten (ör: Sadabat Paktı ve Bağdat Paktı) günümüze (ör: Filistin sorununun çözümüne yönelik yaklaşımlar) Orta Doğu ülkeleriyle ilişkilere özel bir önem atfedildiği görülmektedir.
Muhammed Oral
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Audit of the demographic patterns of oral and maxillofacial surgical cases in a Nigerian teaching hospital

International Journal of Medicine and Health Development, 2011
Background: Surgical audit is a normal part of surgical practice. Earlier reports on the availability of oral and maxillofacial surgical services in Nigeria showed limited number of centres and shortage of specialists. Objective: To determine the pattern
C E Anyanechi, B D Saheeb
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source