Results 241 to 250 of about 1,740,939 (308)

Acute inflammation induced by the Escherichia coli lipopolysaccharide considerably increases the systemic and brain exposure of olanzapine after oral administration in mice. [PDF]

Int J Neuropsychopharmacol
Hubeňák J, Mžik M, Laštůvková H, Bayer D, Jandová L, Schreiberová J, Andrýs C, Mičuda S, Masopust J, Chládek J.   +9 more
europepmc   +1 more source

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Repeated Oral Administration of Ivermectin Belatedly Induces Toxicity and Disrupts the Locomotion and Neuropsychiatric Behavior in Rats. [PDF]

ACS Omega
Comis-Neto AA, Jardim NS, Quines CB, Bianchini MC, Gomes J, Batista WT, de Ávila DS, Haas SE, Rosa SG, Pinton S.   +9 more
europepmc   +1 more source

D‐glucuronyl C5‐Epimerase Binds to EGFR to Suppress Kidney Fibrosis

Advanced Science, EarlyView.
Glucuronyl C5‐epimerase (Hsepi, gene name Glce) is a key enzyme catalyzing heparan sulfate (HS) chain biosynthesis in HS proteoglycans, which are ubiquitously expressed on cell membranes. In normal renal tubular cells, Glce binds to the intracellular domains of EGFR, maintaining stable and orderly EGFR phosphorylation.
Xiaoqi Jing, Jun Wu, Jingru Ning, Xiaoyu Ding, Zhenyun Du, Xiaojiang Wang, Lulin Huang, Ran Wang, Changlin Mei, Kan Ding   +9 more
wiley   +1 more source

Plasma pharmacokinetics, milk residue depletion profile, and milk withdrawal interval estimation following multiple-dose oral administration of meloxicam to lactating dairy goats. [PDF]

Front Vet Sci
Mercer MA, Zhang Z, Clapham MO, Wetzlich SE, Smith FL, Rupchis BA, Lin Z, Tell LA.   +7 more
europepmc   +1 more source

Pharmacokinetics of micronized and water dispersible palmitoylethanolamide in comparison with standard palmitoylethanolamide following single oral administration in male Sprague-Dawley rats.

Indian J Pharmacol
Mehkri S, Dinesh KG, Ashok G, Bopanna K.
europepmc   +1 more source

The pharmacokinetics of brensocatib in participants with renal impairment following a single oral administration. [PDF]

Br J Clin Pharmacol
Yeung SA, Stein DS, Marbury TC, Usansky H.   +3 more
europepmc   +1 more source

Oral Administration of [¹⁸F]MC225 for Quantification of P-glycoprotein Function: A Feasibility Study. [PDF]

Mol Imaging Biol
Salvi de Souza G, Furini CRG, Sijbesma JWA, Kominia M, Doorduin J, Giacobbo BL, Lammertsma AA, Tsoumpas C, Luurtsema G.   +8 more
europepmc   +1 more source

Oral Administration of GnRH and Domperidone via Gel Feed and Their Effect on Reproductive Performance of <i>Devario devario</i> (Bengal Danio), an Ornamental Fish. [PDF]

Gels
Deb S, Biswas P, Singh SK, Waikhom G, Debbarma R, Kashyap S, Lal J, Samal K, Malla S, Yadav NK, Devi NC, Das P, Singh NS, Reddy GD, Irungbam S.   +14 more
europepmc   +1 more source