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Lipid-based nanocarriers for the oral administration of biopharmaceutics.
Nanomedicine, 2016Biopharmaceutics have been recognized as the drugs of choice for the treatment of several diseases, mainly due to their high selectivity and potent action.
T. Karamanidou +3 more
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Dosage Form Developments of Nanosuspension Drug Delivery System for Oral Administration Route.
Current pharmaceutical design, 2015A large amount of new drug candidates are practically insoluble in aqueous solvents and are even simultaneously poorly soluble in organic solvents. Nanosuspension drug delivery system (DDS) was firstly developed in 1994 and has attracted more and more ...
Ang Chen +6 more
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THE ORAL ADMINISTRATION OF ADRENALIN
Endocrinology, 1929That adrenalin is ineffective when administered by mouth seems to be an accepted fact. That it is destroyed by the gastric and intestinal juice is the general belief. Systemic effects from oral administration are thus questionable. Menninger (1927) states that only large doses of adrenalin, when given by mouth, have any effects on the blood pressure of
G. Giragossintz, H. Mackler
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In vivo sensitization to gliadin by oral administration
2023Celiac disease is a highly prevalent immune-mediated enteropathy that develops in genetically susceptible individuals expressing HLA-DQ2 or HLA-DQ8 after ingestion of gluten and results in decreased quality of life and increased morbidity. This pathology is triggered by immunogenic peptides generated from gliadins present in gluten, which act on the ...
Romero Romero, María del Mar +3 more
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Toxogonin: Oral Administration to Man
Journal of Pharmaceutical Sciences, 1971Abstract Toxogonin, administered orally in an aqueous solution to healthy male volunteers, produced dose-related blood levels of oxime. These levels were lower than those found with similar doses of 2-pyridinium aldoxime methochloride. A dose-independent symptom complex of facial warmth and/or numbness and a cool menthol sensation in the throat was ...
Frederick R. Sidell, William A. Groff
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ORAL ADMINISTRATION OF PENICILLIN IN PEDIATRICS
Archives of Pediatrics & Adolescent Medicine, 1947PART 1 A. INTRODUCTION AT PRESENT there are many commercial preparations of penicillin for oral use. Unfortunately, there are conflicting opinions as to its efficacy. This is evidenced in part by the existing disagreement in the literature and likewise by the lack of uniformity of directions for dosage and administration.
Arthur A. Goldfarb +2 more
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Midazolam oral self-administration
Drug and Alcohol Dependence, 1985The technique of chronic schedule-induced drug solution intake was used to determine the possible addiction liability of the short-acting benzodiazepine midazolam. Schedule-induction produces polydipsia over a wide range of fluids as a function of the imposed schedule of food availability. The inducing schedule used presented food pellets automatically
John L. Falk, Maisy Tang
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Safe Administration of Oral Chemotherapy
Clinical Journal of Oncology Nursing, 2003High standards of care are desirable for patients in any setting who receive chemotherapy by any route. Patients who self-administer oral chemotherapy are subject to risks of adverse effects similar to those who receive i.v. chemotherapy. Safeguards to prevent medication error in these patients may not be achieved to the same degree as for patients ...
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Orthopedics and Oral Administration Of Contraceptives
JAMA: The Journal of the American Medical Association, 1970ABSTRACT To the Editor.— A patient, whom I attend, recently called to ask for a refill of her prescription for orally administered contraceptives, not being able to come in herself because she was at total bed rest subsequent to a compression fracture of the second lumbar vertebra.Much discussion in both lay and professional journals concerns a ...
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Oral Administration of Fluorouracil [PDF]
Archives of Surgery, 1968 THE ANTIMETABOLITE, fluorouracil, has been the chemotherapeutic agent of choice in the treatment of advanced cancers of the gastrointestinal tract during recent years. The use of this drug is based on the suggestion that uracil may serve preferentially as a building block for nucleic acid biosynthesis in some tumors. It is believed that fluorouracil or
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