Results 81 to 90 of about 1,810,829 (308)

Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries [PDF]

, 2011
<p><b>Objective:</b> We have previously demonstrated that bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs), is effective in reducing neointimal formation in rodent models of vascular injury by reducing smooth ...
Baker, A.H., Biondi, G., Colombo, A., Di Lauro, M.V., Gordon, P., Grassia, G., Guglielmotti, A., Ialenti, A., Kennedy, S., Maddaluno, M., Maffia, P.   +10 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Investigation of urinary steroid metabolites in calf urine after oral and intramuscular administration of DHEA [PDF]

, 2010
DHEA (3 beta-hydroxy-androst-5-en-17-one) is a natural steroid prohormone. Despite a lack of information on the effect, DHEA and other prohormones are frequently used as a food supplement by body-builders.
Becue, Ilse, Bovee, Toine FH, Nielen, Michel, Rijk, Jeroen CW, Van Peteghem, Carlos, Van Poucke, Christof   +5 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration

Drug Delivery, 2020
The purpose of this study is to evaluate in vitro and in vivo antitumor efficacy and subacute toxicity of triptolide (TP) prodrug, a conjugate between TP and carboxymethyl chitosan (CC).
Huahui Zeng, Xin Zhu, Qikang Tian, Yinyin Yan, Lan Zhang, Min Yan, Ruiqin Li, Xiaofang Li, Guoqiang Wang, Jinlian Ma, Yufang Su, Xiangbo Zhang, Linyu Ma, Zhenqiang Zhang, Xiangxiang Wu   +14 more
doaj   +1 more source

The Yersinia Phage X1 Administered Orally Efficiently Protects a Murine Chronic Enteritis Model Against Yersinia enterocolitica Infection

Frontiers in Microbiology, 2020
Yersinia enterocolitica is generally considered an important food-borne pathogen worldwide, especially in the European Union. A lytic Yersinia phage X1 (Viruses; dsDNA viruses, no RNA stage; Caudovirales; and Myoviridae) was isolated.
Yibing Xue, Shengjie Zhai, Zijing Wang, Yalu Ji, Gang Wang, Tianqi Wang, Xinwu Wang, Hengyu Xi, Ruopeng Cai, Rihong Zhao, Hao Zhang, Lanting Bi, Yuan Guan, Zhimin Guo, Wenyu Han, Wenyu Han, Jingmin Gu   +16 more
doaj   +1 more source

Investigation of effects of two environmental heavy metals in a combined exposure model on the nervous system in rats [PDF]

, 2012
In the present study, the interaction of inhalational and oral exposure to manganese and lead was investigated. Young adult male Wistar rats (2 x 10 per group) were treated orally with MnCl2 (15 and 60 mg/kg b.w.) or Pb acetate (80 and 320 mg/kg) for 3 ...
Horváth, Edina, Máté, Zsuzsanna, Papp, András, Szabó, Andrea   +3 more
core  

Cancer anorexia: hypothalamic activity and its association with inflammation and appetite-regulating peptides in lung cancer [PDF]

, 2017
Background Energy homeostasis is mediated by the hypothalamus, whose inflammation-induced functional derangements contribute to the onset of anorexia in cancer.
Arezzo di Trifiletti, Asakawa, Ayres, Braun, Cangiano, Cooper, DeBoer, Eiler, Engineer, Ezeoke, Fearon, Friedman, Garcia, Gordon, Haehling, Iyer, Jiang, Kilpatrick, Kim, Kullmann, Laviano, Laviano, Laviano, Li, Mantovani, Matsuda, Molfino, Molfino, Molfino, Molfino, Molfino, Muscaritoli, Opara, Page, Purnell, Smeets, Smeets, Smeets, Sánchez-Lara, Torelli   +39 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source