Results 61 to 70 of about 4,117,595 (303)

Oral manifestation of paraneoplastic pemphigus [PDF]

, 2019
Paraneoplastic pemphigus (PNP) is a rare and often fatal autoimmune blistering disease accompanied by both benign and malignant neoplasms. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by PNP patients.
박연정, 최종훈, 권정승, 안형준   +3 more
core   +1 more source

Nanomaterials for oral drug administration

, 2020
In the last decade, a wide variety of oral nano-scaled drug delivery systems have been developed. This book chapter first gives a background on the challenges associated with the design of oral drug formulations, in relation to the well-known barriers ...
Passerini N., Bertoni S., Albertini B.
core   +2 more sources

Intestinal mucosal immune responses induced by oral administration of chitosan nanoparticles encapsulating the PEDV S1 protein

Veterinary Research
Porcine epidemic diarrhea (PED), a highly contagious intestinal disease caused by PEDV, threatens newborn piglets and causes enormous losses in the swine industry. Intestinal mucosal immunity is vital for defense against PEDV.
Kai Su, Jing Ren, Yanan Zhang, Chen Yuan, Yawen Wang, Liu Yang, Lizhi Fu, Tingli Fan, Qinye Song   +8 more
doaj   +1 more source

Predicting Pharmacokinetics of Active Constituents in Spatholobi caulis by Using Physiologically Based Pharmacokinetic Models

Pharmaceuticals
Background/Objectives: Spatholobi Caulis (SPC) is a medicinal plant that mainly grows in China and Southeast Asian countries and commonly used in clinics; the pharmacokinetic characteristics in humans need to be determined.
Xiaoyan Liu, Ruihu Du, Tao Zhang, Yingzi Li, Ludi Li, Zheng Yang, Youbo Zhang, Qi Wang   +7 more
doaj   +1 more source

Micellisation Mechanism and Behaviour of Soluplus®–Furosemide Micelles: Preformulation Studies of an Oral Nanocarrier-Based System

Pharmaceuticals, 2019
: In this study, self-assembling Soluplus® micelles were examined for inherent properties. Through calorimetric analysis, the critical micelle concentration (CMC) could be determined at 25 and 37 °C, and the influence of three media (Milli-Q ...
Julia F. Alopaeus, Ellen Hagesæther, Ingunn Tho   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Aβ Containing Brain Extracts Having Different Effects in Alzheimer’s Disease Transgenic Caenorhabditis elegans and Mice

Frontiers in Aging Neuroscience, 2018
Background: The deposition of β-sheet rich amyloid in senile plaques is a pathological hallmark of Alzheimer’s disease (AD), which is thought to cause neuronal dysfunction.
Yufang Yang, Mo Wang, Ping Yang, Zishan Wang, Li Huang, Jing Xu, Wei Wang, Mei Yu, Liping Bu, Jian Fei, Fang Huang   +10 more
doaj   +1 more source

Guidelines for the administration of oral examinations

Saudi Medical Journal, 2000
Practical oral examinations are considered an important and often a difficult part of medical school examinations. They represent an accurate and direct mean of assessing student9s interaction with patients and their clinical and technical skills. This paper reviews an outline for the administration of oral examinations.
M M, Jan, A R, Al-Buhairi
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Oral administration of glycyrrhizic acid with intramuscular injection of foot-and-mouth disease vaccine enhances the adaptive immune system

Frontiers in Microbiology
BackgroundCommercial foot-and-mouth disease (FMD) vaccines have several drawbacks, including a short duration of the immune response after vaccination and local adverse reactions at the vaccination site. Therefore, we developed a new vaccination strategy
Seokwon Shin, Hyeong Won Kim, Mi-Kyeong Ko, So Hui Park, Jong-Hyeon Park, Su-Mi Kim, Min Ja Lee   +6 more
doaj   +1 more source