Results 41 to 50 of about 1,810,829 (308)

Lipid Nanoparticles-Encapsulated YF4: A Potential Therapeutic Oral Peptide Delivery System for Hypertension Treatment

Frontiers in Pharmacology, 2019
Drugs are administered orally in the clinical treatment of hypertension. Antihypertensive peptides have excellent angiotensin converting enzyme inhibitors activity in vitro.
Shengnan Zhao, Jinhua Li, Jinhua Li, Yang Zhou, Yang Zhou, Lingjing Huang, Yanfei Li, Juanjuan Xu, Chunmei Fu, Xia Guo, Jian Yang   +10 more
doaj   +1 more source

Effects of Oral Exposure to Mn-Doped ZnS Quantum Dots on Intestinal Tract and Gut Microbiota in Mice

Frontiers in Physiology, 2021
Mn-doped ZnS quantum dots (QDs) with excellent optical properties have been explored in a wide range of fields. Their potential adverse effects on biological systems and human health should be evaluated before biological application. In the present study,
Yanjie Yang, Ruixue Xia, Xiaomei Zhang, Xu Wang, Yuchen Zhou, Honggang Wang, Yu Feng, Shuangyu Lv, Shaoping Ji   +8 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Development of a Compartment Model to Study the Pharmacokinetics of Medical THC after Oral Administration

Computation
The therapeutic potential of delta9-tetrahydrocannabinol (THC), a primary cannabinoid in the cannabis plant, has led to its development into oral medical products for treating various conditions.
Thanachok Mahahong, Teerapol Saleewong
doaj   +1 more source

Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. [PDF]

, 2016
BackgroundClenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in
Chouicha, Nadira, Harrison, Linda M, Kass, Phil H, Knych, Heather K, Steinmetz, Stacy J   +4 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Repeated, low-dose oral esketamine in patients with treatment-resistant depression: pilot study

BJPsych Open, 2022
Background Intravenous infusion of ketamine can produce rapid and large symptom reduction in patients with treatment-resistant depression (TRD) but presents major obstacles to clinical applicability, especially in community settings. Oral esketamine may
Sanne Y. Smith-Apeldoorn, Jolien K. E. Veraart, Henricus G. Ruhé, Marije aan het Rot, Jeanine Kamphuis, Marrit K. de Boer, Robert A. Schoevers   +6 more
doaj   +1 more source

Picoliter-volume inkjet printing into planar microdevice reservoirs for low-waste, high-capacity drug loading. [PDF]

, 2017
Oral delivery of therapeutics is the preferred route for systemic drug administration due to ease of access and improved patient compliance. However, many therapeutics suffer from low oral bioavailability due to low pH and enzymatic conditions, poor ...
Bogdanoff, Derek B, Cantlon, Joshua, Chevalier, Rachel W, Desai, Tejal A, Fox, Cade B, Hsiao, Jeff C, Nemeth, Cameron L   +6 more
core   +1 more source

Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. [PDF]

, 2020
Oxidative stress and chronic inflammation play critical roles in the pathogenesis of ulcerative colitis (UC) and inflammatory bowel diseases (IBD). A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium ...
Farzaneh, Ted, Ichii, Hirohito, Lau, Hien, Li, Shiri, Robles, Lourdes, Stamos, Michael J, Takasu, Chie, Vaziri, Nosratola D, Vo, Kelly   +8 more
core   +2 more sources