Results 21 to 30 of about 830,786 (265)

Recent Advances in Oral Peptide or Protein-Based Drug Liposomes

Pharmaceuticals, 2022
The high physiology and low toxicity of therapeutic peptides and proteins have made them a hot spot for drug development in recent years. However, their poor oral bioavailability and unstable metabolism make their clinical application difficult.
Jian Cui, Zhiwei Wen, Wei Zhang, Wei Wu
doaj   +1 more source

Genotoxic evaluation of polymeric nanoparticles

Frontiers in Genetics, 2015
An important strategy for optimizing the therapeutic efficacy of many conventional drugs is the development of polymeric nanoparticles (NPs), as it may expand their activities, reduce their toxicity, increase their bioactivity and improve biodistribution.
Tamara Iglesias Alonso
doaj   +1 more source

Recent Progress in Diatom Biosilica: A Natural Nanoporous Silica Material as Sustained Release Carrier

Pharmaceutics, 2023
A drug delivery system (DDS) is a useful technology that efficiently delivers a target drug to a patient’s specific diseased tissue with minimal side effects.
Hayeon Lim, Yoseph Seo, Daeryul Kwon, Sunggu Kang, Jiyun Yu, Hyunjun Park, Sang Deuk Lee, Taek Lee   +7 more
doaj   +1 more source

Lipid Nanoparticles-Encapsulated YF4: A Potential Therapeutic Oral Peptide Delivery System for Hypertension Treatment

Frontiers in Pharmacology, 2019
Drugs are administered orally in the clinical treatment of hypertension. Antihypertensive peptides have excellent angiotensin converting enzyme inhibitors activity in vitro.
Shengnan Zhao, Jinhua Li, Jinhua Li, Yang Zhou, Yang Zhou, Lingjing Huang, Yanfei Li, Juanjuan Xu, Chunmei Fu, Xia Guo, Jian Yang   +10 more
doaj   +1 more source

GENERAL ANALGESIA BY ORAL ADMINISTRATION [PDF]

BMJ, 1918
This report is in the nature of a preliminary communication based on animal experiments and a sufficient number of clinical cases to support the conclusions of the animal work. It will be seen that general analgesia in which there is loss of sensation, with or without loss of consciousness, can be established for otherwise painful dressings and for ...
J T, Gwathmey, H T, Karsner
openaire   +2 more sources

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

Development of a Compartment Model to Study the Pharmacokinetics of Medical THC after Oral Administration

Computation
The therapeutic potential of delta9-tetrahydrocannabinol (THC), a primary cannabinoid in the cannabis plant, has led to its development into oral medical products for treating various conditions.
Thanachok Mahahong, Teerapol Saleewong
doaj   +1 more source

Anti-Inflammatory Activity of Chlorogenic Acid on Macrophages: A Simplified Simulation of Pharmacokinetics Following Ingestion Using a Windup Syringe Pump

Applied Sciences, 2023
Cell-culture-based drug tests are usually performed in an instantaneous delivery manner. However, in vivo pharmacokinetic studies have shown a steady increase in the concentration of bioactive compounds in the plasma following oral administration, with ...
Lei Cao, Won Han, Sang Gil Lee, Joong Ho Shin   +3 more
doaj   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Orally administrated Lactobacillus gasseri TM13 and Lactobacillus crispatus LG55 can restore the vaginal health of patients recovering from bacterial vaginosis

Frontiers in Immunology, 2023
Bacterial vaginosis (BV) is a common infection of the lower genital tract with a vaginal microbiome dysbiosis caused by decreasing of lactobacilli. Previous studies suggested that supplementation with live Lactobacillus may benefit the recovery of BV ...
Fengyuan Qi, Fengyuan Qi, Fengyuan Qi, Fengyuan Qi, Shangrong Fan, Shangrong Fan, Shangrong Fan, Chao Fang, Chao Fang, Lan Ge, Jinli Lyu, Jinli Lyu, Jinli Lyu, Zhuoqi Huang, Zhuoqi Huang, Zhuoqi Huang, Shaowei Zhao, Shaowei Zhao, Yuanqiang Zou, Yuanqiang Zou, Liting Huang, Liting Huang, Liting Huang, Xinyang Liu, Xinyang Liu, Xinyang Liu, Yiheng Liang, Yiheng Liang, Yiheng Liang, Yongke Zhang, Yongke Zhang, Yongke Zhang, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Liang Xiao, Xiaowei Zhang, Xiaowei Zhang, Xiaowei Zhang   +38 more
doaj   +1 more source