Results 11 to 20 of about 1,810,829 (308)
Toxins, 2021 Microcystins are common freshwater cyanobacterial toxins that affect liver function. The toxicities of five microcystin congeners (microcystin-LA (MCLA), MCLR, MCLY, MCRR, and MCYR) commonly observed in harmful algal blooms (HABs) were evaluated in BALB ...
Neil Chernoff +5 more
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Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration under Similar Systemic Exposures [PDF]
, 2019 Objective To test whether an individual's subjective responses to alcohol are similar when the breath alcohol concentration (BrAC) trajectory resulting from oral administration is matched by intravenous administration.
Boes, Julian +6 more
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Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]
, 2019 Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe +9 more
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Pharmaceutics, 2023 Gefitinib (GEF) is a clinical medication for the treatment of lung cancer targeting the epidermal growth factor receptor (EGFR). However, its efficacy is remarkably limited by low solubility and dissolution rates.
Muhammad Inam +10 more
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Intravenous Voriconazole after Toxic Oral Administration [PDF]
Antimicrobial Agents and Chemotherapy, 2010 ABSTRACT In a male patient with rhinocerebral invasive aspergillosis, prolonged high-dosage oral administration of voriconazole led to hepatotoxicity combined with a severe cutaneous reaction while intravenous administration in the same patient did not.
Alffenaar, J.W.C. +5 more
openaire +2 more sources
Prodrugs for Improved Drug Delivery: Lessons Learned from Recently Developed and Marketed Products
Pharmaceutics, 2020 Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a parent drug in the body. In the past, prodrugs were used as a last option; however, nowadays, prodrugs are considered already in the early stages of drug ...
Milica Markovic +2 more
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Antithrombotic Activity of Heparinoid G2 and Its Derivatives from the Clam Coelomactra antiquata
Marine Drugs, 2022 Clam heparinoid G2 (60.25 kDa) and its depolymerized derivatives DG1 (24.48 kDa) and DG2 (6.75 kDa) prepared from Coelomactra antiquata have been documented to have excellent fibrinolytic and anticoagulant activity.
Guanlan Chen +7 more
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Expression and Purification of a PEDV-Neutralizing Antibody and Its Functional Verification
Viruses, 2021 Porcine epidemic diarrhea virus (PEDV) is a highly infectious and pathogenic virus causing high morbidity and mortality, especially in newborn piglets. There remain problems with contemporary PEDV vaccines, in part because of the rapid variation of PEDV,
Wenshu Shi +6 more
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Oral Administration of Bacitracin
Experimental Biology and Medicine, 1948 SummaryFrom the small series of animals receiving oral bacitracin, the following significant facts were obtained: 1. Fecal streptococci and spore forming anaerobes were greatly reduced in the intestine at a dosage between 2,000 and 10,000 u/kg per day. 2. Coliform organisms were little affected by bacitracin. 3.
G. C. Bond +3 more
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GENERAL ANALGESIA BY ORAL ADMINISTRATION [PDF]
BMJ, 1918 This report is in the nature of a preliminary communication based on animal experiments and a sufficient number of clinical cases to support the conclusions of the animal work. It will be seen that general analgesia in which there is loss of sensation, with or without loss of consciousness, can be established for otherwise painful dressings and for ...
J T, Gwathmey, H T, Karsner
openaire +2 more sources