Results 191 to 200 of about 162,747 (308)

Validated RP‐HPLC–UV Method for the Quantitative Analysis and Stability Evaluation of Amoxicillin in Paediatric Gummy Tablets

ELECTROPHORESIS, EarlyView.
A validated RP‐HPLC–UV method was successfully applied for amoxicillin determination in gummy tablets. The method is useful for an accurate amoxicillin content determination in paediatric gummies and was applied to study the stability profile of the drug, evaluated over 6 months under storage conditions.
Samuele Bonafè, Anna Imbriano, Cinzia Pagano, Anna Migni, Elisa Bianconi, Laura Mercolini, Luana Perioli, Roccaldo Sardella   +7 more
wiley   +1 more source

QSAR Models for Predicting Oral Bioavailability and Volume of Distribution and Their Application in Mapping the TK Space of Endocrine Disruptors. [PDF]

J Xenobiot
Ollitrault G, Marzo M, Roncaglioni A, Benfenati E, Taboureau O, Mombelli E.   +5 more
europepmc   +1 more source

Cenobamate use in super‐refractory status epilepticus: A report of three cases

Epileptic Disorders, EarlyView.
Abstract Objectives Super‐refractory status epilepticus (SRSE) is a neurological emergency with high morbidity and mortality. Cenobamate, a novel antiseizure medication, may be helpful in managing SRSE, but evidence is limited. Methods This retrospective case series reports the use of cenobamate as add‐on therapy in the management of three cases of ...
Marina Romozzi, Juan Luis Alcala‐Zermeno, Antonio Funcis, Federico Tosto, Marta Piccioli, Luigi Francesco Iannone, Riccardo Maviglia, Masahito Katsuki, Yasuhiko Matsumori, Paolo Calabresi, Raffaele Iorio, Catello Vollono   +11 more
wiley   +1 more source

A primary human Gut/Liver microphysiological system to estimate human oral bioavailability. [PDF]

Drug Metab Dispos
Abbas Y, van Wyk M, Sze H, Christophi J, Spreen AA, Bliton RJ, Boazak EM, Kostrzewski T.   +7 more
europepmc   +1 more source

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Lymph-Targeted Delivery of CUR-NLCs Enhances Oral Bioavailability: Evidence from a Double-Catheterized Rat Model. [PDF]

Pharmaceutics
Chi H, Zhang X, Chen Z, Chen Q, Yang B, Deng H, Yu D.   +6 more
europepmc   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

New Multiparameter Index Is a Strong Predictor of Oral Bioavailability for Heterobifunctional Degraders. [PDF]

ACS Med Chem Lett
Baylon JL, Chalkley MJ, Siu T, Shou W, Sun Y, Cai X, Paiva A, Patel S, Zvyaga T, Weiss DR.   +9 more
europepmc   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Development of a nanoemulsion incorporating 3-acetyl-11-keto-β-boswellic acid (AKBA): solubility and oral bioavailability through in vitro and in vivo studies. [PDF]

BMC Biotechnol
Ketabchi N, Ostad SN, Ghazi-Khansari M, Ghanbari H, Esmaeili F, Amani A.   +5 more
europepmc   +1 more source