Results 171 to 180 of about 261,112 (210)

Bioavailability and pharmacology of oral idarubicin

Cancer Chemotherapy and Pharmacology, 1991
A total of 9 patients entered in a phase I trial who received oral idarubicin daily for 3 days took part in pharmacokinetic studies, and bioavailability studies were performed on 13 additional patients receiving single doses of oral idarubicin alternating with i.v. treatment.
D J, Stewart, D, Grewaal, R M, Green, S, Verma, J A, Maroun, D, Redmond, L, Robillard, S, Gupta   +7 more
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Bioavailability of oral isbufylline in rabbits

European Journal of Drug Metabolism and Pharmacokinetics, 1992
The bioavailability of isbufylline was assessed in male rabbits given 12 mg/kg i.v. (intravenous) or per os (oral) according to a randomized design. The concentrations of unbound (fu = 54.0) isbufylline were considered in plasma as a function of time, after i.v. and oral administration. After oral administration in saline solution, a mean absolute oral
A, Celardo, G, Dell'Elba, M, Bonati
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Linezolid absolute bioavailability and the effect of food on oral bioavailability

Biopharmaceutics & Drug Disposition, 2001
AbstractLinezolid is a novel oxazolidinone antibiotic that has a spectrum of activity encompassing a variety of Gram‐positive bacteria. The objectives of this study were twofold: (1) to compare the absorption of linezolid tablets given immediately following a high‐fat meal with the absorption of tablets administered while fasting, and (2) to assess the
I R, Welshman, T A, Sisson, G L, Jungbluth, D J, Stalker, N K, Hopkins   +4 more
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Strategies for enhancing the oral bioavailability of cannabinoids

Expert Opinion on Drug Metabolism & Toxicology, 2022
Oral administration of cannabinoids is a convenient route of administration in many cases. To enhance the poor and variable bioavailability of cannabinoids, selected strategies utilizing proper delivery systems have been designed. Low solubility in the GI aqueous media is the first and most critical barrier.
Ayala, Bar-Hai, Abraham J, Domb, Amnon, Hoffman   +2 more
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The Impact of ΔG on the Oral Bioavailability of Low Bioavailable Therapeutic Agents

The Journal of Pharmacology and Experimental Therapeutics, 2005
Low oral bioavailability continues to drive research toward identifying novel approaches to enhance drug delivery. Over the past few years, emphasis on the use of absorption enhancers has been overwhelming despite their major adverse effects. Zonula occludens toxin (Zot) was recently established as a safe and effective absorption enhancer, reversibly ...
Noha N, Salama, Alessio, Fasano, Manjusha, Thakar, Natalie D, Eddington   +3 more
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Bioavailability and Bioavailable Forms of Collagen after Oral Administration to Rats

Journal of Agricultural and Food Chemistry, 2015
The bioavailability and bioavailable forms of collagen after oral administration to rats were investigated in this study. The relative and absolute bioavailability of collagen were 57.8% and 49.6%, respectively, which was indirectly evaluated by the bioavailability of Hyp in collagen using a pharmacokinetic method.
Lin, Wang, Qing, Wang, Jing, Qian, Qiufang, Liang, Zhenbin, Wang, Junmin, Xu, Song, He, Haile, Ma   +7 more
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Bioavailability of Soil-Bound TCDD: Oral Bioavailability in the Rat

Toxicological Sciences, 1988
The implications to the public health of trace amounts of 2,3,7,8-TCDD in the environment are under evaluation by regulatory agencies in the United States and Western Europe. One major consideration in such evaluations is the contribution to human exposure via ingestion of TCDD-contaminated soil.
H, Shu, P, Teitelbaum, A S, Webb, L, Marple, B, Brunck, D, Dei Rossi, F J, Murray, D, Paustenbach   +7 more
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Pharmacokinetics and bioavailability of oral and intramuscular artemether

European Journal of Clinical Pharmacology, 1997
The pharmacokinetics and bioavailability of artemether and dihydroartemisinin were investigated in eight Thai males following the administration of single oral and intramuscular doses of artemether (300 mg) in a randomized two-way cross-over study.Both oral and intramuscular artemether were well-tolerated.
J, Karbwang, K, Na-Bangchang, K, Congpuong, P, Molunto, A, Thanavibul   +4 more
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The Effect of Mannitol on the Oral Bioavailability of Cimetidine

Journal of Pharmaceutical Sciences, 1995
The aim of the study was to investigate whether mannitol at amounts relevant to pharmaceutical formulations would alter the oral bioavailability of cimetidine, a drug primarily absorbed from the small bowel. Seven healthy male subjects each received four formulations, a chewable tablet or a solution, containing 0.200 g of cimetidine and either 2.264 g ...
D A, Adkin, S S, Davis, R A, Sparrow, P D, Huckle, I R, Wilding   +4 more
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Increasing oral bioavailability of progesterone by formulation

Journal of Steroid Biochemistry, 1978
Abstract Admixture of cholesterol trimethyl acetate to progesterone in proportions that formed solid solutions resulted in significant increase of oral bio-availability in humans. Studies in rats have indicated that increased effectiveness was achieved by increasing lymph absorption.
F A, Kincl, L A, Ciaccio, G, Benagiano
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