Results 161 to 170 of about 261,112 (210)

Oral bioavailability of clonidine in children

Pediatric Anesthesia, 2010
SummaryBackground: Oral clonidine is used as premedication in children. The bioavailability of clonidine given orally in adults is 75–100% but is unknown in children.Methods: Children (3–10 years) undergoing adenotonsillectomy were administered oral clonidine 4 mcg·kg−1mixed with apple fruit drink as premedication.
Peter, Larsson, Anders, Nordlinder, Henrik T G, Bergendahl, Per-Arne, Lönnqvist, Staffan, Eksborg, Nicole, Almenrader, Brian J, Anderson   +6 more
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Studies of the oral bioavailability of alendronate*

Clinical Pharmacology & Therapeutics, 1995
Clinical studies were performed to examine the oral bioavailability of alendronate (4-amino-1-hydroxy-butylidene-1,1-bisphosphonate monosodium). All studies, with the exception of one performed in men, involved postmenopausal women. Short-term (24 to 36 hours) urinary recovery of alendronate after an intravenous dose of 125 to 250 micrograms averaged ...
B J, Gertz, S D, Holland, W F, Kline, B K, Matuszewski, A, Freeman, H, Quan, K C, Lasseter, J C, Mucklow, A G, Porras   +8 more
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Variable Bioavailability of Oral Melatonin

New England Journal of Medicine, 1997
To the Editor: It has been claimed that melatonin has many actions, mostly on the basis of uncontrolled studies of widely varying oral doses. It is commonly assumed that the administered dosage of melatonin bears a direct relation to its circulating concentration. We estimated the bioavailability of oral melatonin by determining the pharmacokinetics of
W L, Di, A, Kadva, A, Johnston, R, Silman   +3 more
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Pharmacokinetics and Oral Bioavailability of Hydrocortisone

The Journal of Clinical Pharmacology, 1991
The pharmacokinetics of 20 mg hydrocortisone were studied after IV and oral administration. Endogenous hydrocortisone was suppressed by dexamethasone administration. Hydrocortisone concentrations were measured in plasma and saliva. After IV administration, hydrocortisone was eliminated with a total body clearance of 18 L/hr and a half‐life of 1.7 hr ...
H, Derendorf, H, Möllmann, J, Barth, C, Möllmann, S, Tunn, M, Krieg   +5 more
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Oral bioavailability of mesna tablets

Cancer Chemotherapy and Pharmacology, 1993
To test the feasibility of uroprotection with sodium 2-mercaptoethane-sulfonate (mesna) in tablet form the bioavailability of mesna tablets was determined in healthy volunteers by HPLC. The area under the plasma concentration-time curve (AUC) of free mesna was significantly lower following oral (110 mumol.l-1 x h-1; 95% CI 98-122) than following i.v ...
Stofer-Vogel B, Cerny T, Borner M, Lauterburg BH   +3 more
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Bioavailability of oral testosterone in males

European Journal of Clinical Pharmacology, 1979
Twenty-six male volunteers received a single oral dose of testosterone as free crystals or as the undecanoate ester. The latter was given either in crystalline form or in arachis oil. All preparations were tested three times in the same individual, whilst fasting on 2 days and on one day together with a breakfast rich in fat.
H, Frey, A, Aakvaag, D, Saanum, J, Falch
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Bioavailability of Oral Melatonin in Humans

Neuroendocrinology, 1984
We administered crystalline melatonin (80 mg) in gelatin capsules to 5 young male volunteers and measured serum and urinary melatonin levels at intervals. Changes in serum melatonin levels were best described by a biexponential equation with an absorption constant (ka) of 1.72 h-1 (half-life = 0.40 h) and an elimination constant (ke1) of 0.87 h-1 (half-
F, Waldhauser, M, Waldhauser, H R, Lieberman, M H, Deng, H J, Lynch, R J, Wurtman   +5 more
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Absolute bioavailability of oral theophylline

American Journal of Health-System Pharmacy, 1977
The absolute bioavailability of theophylline was investigated by comparing the areas under concentration-time curves for intravenous theophylline with a plain uncoated anhydrous theophylline tablet and a theophylline solution. Twenty asthmatic adults received approximately 7.5 mg/kg theophylline intravenously over 30 minutes; either seven days before ...
L, Hendeles, M, Weinberger, L, Bighley
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Bioavailability of Oral and Intramuscular Phenobarbital

The Journal of Clinical Pharmacology, 1978
The absorption of phenobarbital was compared in healthy adult subjects after oral and intramuscular therapeutic doses. Serum levels of phenobarbital were determined for 21 days after dosing by means of radioimmunoassay. Serum levels were similar from both dosage routes, with peak levels occurring at 1-3 hours after dosing and then declining slowly with
C T, Viswanathan, H E, Booker, P G, Welling   +2 more
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Predicting Oral Absorption and Bioavailability

2003
Publisher Summary The prediction of oral absorption and bioavailability is an important tool, both in the early phases of drug discovery to select the most promising leads for further optimization and in the later stages to select candidates for clinical development.
Han, van de Waterbeemd, Barry C, Jones
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