Results 291 to 300 of about 2,176,373 (353)

Bioavailability of oral testosterone in males

European Journal of Clinical Pharmacology, 1979
Twenty-six male volunteers received a single oral dose of testosterone as free crystals or as the undecanoate ester. The latter was given either in crystalline form or in arachis oil. All preparations were tested three times in the same individual, whilst fasting on 2 days and on one day together with a breakfast rich in fat.
H, Frey, A, Aakvaag, D, Saanum, J, Falch
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Bioavailability of cyclophosphamide from oral formulations

European Journal of Clinical Pharmacology, 1984
Cyclophosphamide (CP) is an alkylating cytostatic compound, which is activated to its cytotoxic form in the liver [1]. Since the therapeutic range of CP in the treatment of human tumours, is small like other cytostatics, a constant high bioavailability is essential for its oral administration.
T, Wagner, K, Fenneberg
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Drug-Phospholipid Complex—a Go Through Strategy for Enhanced Oral Bioavailability

AAPS PharmSciTech, 2019
Among many, the oral route of delivery is considered to be the most favorable route with the highest patient compliance. The main issue with oral delivery is the environmental vulnerability of gastro intestinal tract (G.I.T).
Kaushik Kuche, Nallamothu Bhargavi, C. Dora, Sanyog Jain   +3 more
semanticscholar   +1 more source

Bioavailability of Oral Melatonin in Humans

Neuroendocrinology, 1984
We administered crystalline melatonin (80 mg) in gelatin capsules to 5 young male volunteers and measured serum and urinary melatonin levels at intervals. Changes in serum melatonin levels were best described by a biexponential equation with an absorption constant (ka) of 1.72 h-1 (half-life = 0.40 h) and an elimination constant (ke1) of 0.87 h-1 (half-
F, Waldhauser, M, Waldhauser, H R, Lieberman, M H, Deng, H J, Lynch, R J, Wurtman   +5 more
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Bioavailability of Oral and Intramuscular Phenobarbital

The Journal of Clinical Pharmacology, 1978
The absorption of phenobarbital was compared in healthy adult subjects after oral and intramuscular therapeutic doses. Serum levels of phenobarbital were determined for 21 days after dosing by means of radioimmunoassay. Serum levels were similar from both dosage routes, with peak levels occurring at 1-3 hours after dosing and then declining slowly with
C T, Viswanathan, H E, Booker, P G, Welling   +2 more
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Pharmacokinetics and Oral Bioavailability of Hydrocortisone

The Journal of Clinical Pharmacology, 1991
The pharmacokinetics of 20 mg hydrocortisone were studied after IV and oral administration. Endogenous hydrocortisone was suppressed by dexamethasone administration. Hydrocortisone concentrations were measured in plasma and saliva. After IV administration, hydrocortisone was eliminated with a total body clearance of 18 L/hr and a half‐life of 1.7 hr ...
H, Derendorf, H, Möllmann, J, Barth, C, Möllmann, S, Tunn, M, Krieg   +5 more
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Explorations into modeling human oral bioavailability

European Journal of Medicinal Chemistry, 2008
Explorations into modeling human oral bioavailability started with a whole dataset of 772 drug compounds. First, training set and test set were chosen based on Kohonen's self-organizing Neural Network (KohNN). Then, a quantitative model of the whole dataset was built using multiple linear regression (MLR) analysis. This model had limited predictability
Zhi, Wang, Aixia, Yan, Qipeng, Yuan, Johann, Gasteiger   +3 more
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Bioavailability and pharmacology of oral idarubicin

Cancer Chemotherapy and Pharmacology, 1991
A total of 9 patients entered in a phase I trial who received oral idarubicin daily for 3 days took part in pharmacokinetic studies, and bioavailability studies were performed on 13 additional patients receiving single doses of oral idarubicin alternating with i.v. treatment.
D J, Stewart, D, Grewaal, R M, Green, S, Verma, J A, Maroun, D, Redmond, L, Robillard, S, Gupta   +7 more
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Preparation of curcumin-hydroxypropyl-β-cyclodextrin inclusion complex by cosolvency-lyophilization procedure to enhance oral bioavailability of the drug

Drug Development and Industrial Pharmacy, 2018
The curcumin (CUR)-hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex (CUR-HP-β-CD) was prepared to erase its therapeutic restrictions of poor aqueous solubility and low oral bioavailability.
Ningli Li, Ning Wang, Tingni Wu, Changlu Qiu, Xueting Wang, Shaohong Jiang, Zina Zhang, Ting Liu, Chunliu Wei, Ting Wang   +9 more
semanticscholar   +1 more source

Bioavailability of oral isbufylline in rabbits

European Journal of Drug Metabolism and Pharmacokinetics, 1992
The bioavailability of isbufylline was assessed in male rabbits given 12 mg/kg i.v. (intravenous) or per os (oral) according to a randomized design. The concentrations of unbound (fu = 54.0) isbufylline were considered in plasma as a function of time, after i.v. and oral administration. After oral administration in saline solution, a mean absolute oral
A, Celardo, G, Dell'Elba, M, Bonati
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