Results 271 to 280 of about 162,747 (308)

Strategies for enhancing the oral bioavailability of cannabinoids

Expert Opinion on Drug Metabolism & Toxicology, 2022
Oral administration of cannabinoids is a convenient route of administration in many cases. To enhance the poor and variable bioavailability of cannabinoids, selected strategies utilizing proper delivery systems have been designed. Low solubility in the GI aqueous media is the first and most critical barrier.
Ayala, Bar-Hai, Abraham J, Domb, Amnon, Hoffman   +2 more
openaire   +2 more sources

The Impact of ΔG on the Oral Bioavailability of Low Bioavailable Therapeutic Agents

The Journal of Pharmacology and Experimental Therapeutics, 2005
Low oral bioavailability continues to drive research toward identifying novel approaches to enhance drug delivery. Over the past few years, emphasis on the use of absorption enhancers has been overwhelming despite their major adverse effects. Zonula occludens toxin (Zot) was recently established as a safe and effective absorption enhancer, reversibly ...
Noha N, Salama, Alessio, Fasano, Manjusha, Thakar, Natalie D, Eddington   +3 more
openaire   +2 more sources

Bioavailability and Bioavailable Forms of Collagen after Oral Administration to Rats

Journal of Agricultural and Food Chemistry, 2015
The bioavailability and bioavailable forms of collagen after oral administration to rats were investigated in this study. The relative and absolute bioavailability of collagen were 57.8% and 49.6%, respectively, which was indirectly evaluated by the bioavailability of Hyp in collagen using a pharmacokinetic method.
Lin, Wang, Qing, Wang, Jing, Qian, Qiufang, Liang, Zhenbin, Wang, Junmin, Xu, Song, He, Haile, Ma   +7 more
openaire   +2 more sources

Bioavailability of Soil-Bound TCDD: Oral Bioavailability in the Rat

Toxicological Sciences, 1988
The implications to the public health of trace amounts of 2,3,7,8-TCDD in the environment are under evaluation by regulatory agencies in the United States and Western Europe. One major consideration in such evaluations is the contribution to human exposure via ingestion of TCDD-contaminated soil.
H, Shu, P, Teitelbaum, A S, Webb, L, Marple, B, Brunck, D, Dei Rossi, F J, Murray, D, Paustenbach   +7 more
openaire   +3 more sources

Increasing oral bioavailability of progesterone by formulation

Journal of Steroid Biochemistry, 1978
Abstract Admixture of cholesterol trimethyl acetate to progesterone in proportions that formed solid solutions resulted in significant increase of oral bio-availability in humans. Studies in rats have indicated that increased effectiveness was achieved by increasing lymph absorption.
F A, Kincl, L A, Ciaccio, G, Benagiano
openaire   +2 more sources

Bioavailability and Pharmacokinetics of Oral Dopamine in Dogs

Journal of Pharmaceutical Sciences, 1988
The bioavailability and pharmacokinetics of oral dopamine (DA) were studied in dogs. Plasma concentrations of DA and its main metabolites, such as dopamine-3-O-sulfate (DA-SO4) and 3,4-dihydroxyphenyl acetic acid (DOPAC) were determined after intravenous or oral administration of DA using high-performance liquid chromatography with electrochemical ...
K, Murata, K, Noda, K, Kohno, M, Samejima   +3 more
openaire   +2 more sources

The utility of cyclodextrins for enhancing oral bioavailability

Journal of Controlled Release, 2007
Cyclodextrins (CD) have been utilized extensively in pharmaceutical formulations to enhance oral bioavailability. A critical review of the literature in which cyclodextrins were utilized for this purpose was conducted. The goal of this review was to determine if quantitative guidelines for drug and cyclodextrin properties necessary for bioavailability ...
Rebecca L, Carrier, Lee A, Miller, Imran, Ahmed   +2 more
openaire   +2 more sources

In Silico Prediction of Oral Bioavailability

2007
Preclinical predictive models of human oral bioavailability would be of considerable benefit to pharmaceutical product development. Identification of potentially orally bioavailable compounds may assist in candidate selection, or compounds with poor projected bioavailability may be identified early, saving potential late failure and, thus ...
Turner, Joseph, Agatonovic-Kustrin, Snezana   +1 more
openaire   +3 more sources

Pharmacokinetics and bioavailability of oral and intramuscular artemether

European Journal of Clinical Pharmacology, 1997
The pharmacokinetics and bioavailability of artemether and dihydroartemisinin were investigated in eight Thai males following the administration of single oral and intramuscular doses of artemether (300 mg) in a randomized two-way cross-over study.Both oral and intramuscular artemether were well-tolerated.
J, Karbwang, K, Na-Bangchang, K, Congpuong, P, Molunto, A, Thanavibul   +4 more
openaire   +2 more sources

The Effect of Mannitol on the Oral Bioavailability of Cimetidine

Journal of Pharmaceutical Sciences, 1995
The aim of the study was to investigate whether mannitol at amounts relevant to pharmaceutical formulations would alter the oral bioavailability of cimetidine, a drug primarily absorbed from the small bowel. Seven healthy male subjects each received four formulations, a chewable tablet or a solution, containing 0.200 g of cimetidine and either 2.264 g ...
D A, Adkin, S S, Davis, R A, Sparrow, P D, Huckle, I R, Wilding   +4 more
openaire   +2 more sources