Results 251 to 260 of about 162,747 (308)

Enhancement of cannabidiol oral bioavailability through the development of nanostructured lipid carriers: In vitro and in vivo evaluation studies. [PDF]

Drug Deliv Transl Res
Taha IE, ElSohly MA, Radwan MM, Elkanayati RM, Wanas A, Joshi PH, Ashour EA.   +6 more
europepmc   +1 more source

The Synthesis of SNAC Phenolate Salts and the Effect on Oral Bioavailability of Semaglutide. [PDF]

Molecules
Shapira-Furman T, Bar-Hai A, Hoffman A, Domb AJ.   +3 more
europepmc   +1 more source

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Bioavailability of oral dexamethasone

Clinical Pharmacology & Therapeutics, 1975
Bioavailabilities of dexamethasone tablets and elixir in man were evaluated by each of 3 model‐independent methods of pharmacokinetic analysis employing plasma and urinary values as determined by radioimmune assay. There were no significant differences among the results determined by the 3 methods nor between the respective availabilities of the !Wo ...
D E, Duggan, K C, Yeh, N, Matalia, C A, Ditzler, F G, McMahon   +4 more
openaire   +2 more sources

The Bioavailability of Oral Nitroglycerin

Journal of Pharmaceutical Sciences, 1986
In the 1970's, the efficacy of oral nitroglycerin therapy was seriously challenged, primarily on the basis of animal studies showing complete first-pass hepatic metabolism of nitroglycerin. Today, it is generally accepted that high oral doses of nitroglycerin do show antianginal efficacy. It has been suggested that this efficacy results from saturation
P K, Noonan, L Z, Benet
openaire   +2 more sources

Bioavailability of oral micronized progesterone

Fertility and Sterility, 1985
Progesterone (P) has not been administered orally because of reportedly poor bioavailability and a rapid clearance rate. Unfortunately, the synthetic derivatives, although orally active, have a number of disadvantages and fail to mimic natural P completely.
W S, Maxson, J T, Hargrove
openaire   +2 more sources

The Absolute Bioavailability of Oral Melatonin

The Journal of Clinical Pharmacology, 2000
The absolute bioavailability of oral melatonin tablets was studied in 12 normal healthy volunteers. Subjects were administered, in a randomized crossover fashion, melatonin 2 mg intravenously and 2 and 4 mg orally. Blood was sampled over approximately eight (estimated) half‐lives.
R L, DeMuro, A N, Nafziger, D E, Blask, A M, Menhinick, J S, Bertino   +4 more
openaire   +2 more sources

Oral Bioavailability

2010
Soil ingestion is a key exposure pathway in Human Health Risk Assessment for contaminants in soil. The theory and mechanisms of how contaminants in a soil enter the human body through the gastrointestinal tract are outlined. The methods available for measuring human exposure using human, animal and validated in-vitro laboratory methods are described ...
Cave, Mark, Wragg, Joanna, Denys, Sébastien, Jondreville, Catherine, Feidt, Cyril   +4 more
openaire   +3 more sources

Oral bioavailability of clonidine in children

Pediatric Anesthesia, 2010
SummaryBackground: Oral clonidine is used as premedication in children. The bioavailability of clonidine given orally in adults is 75–100% but is unknown in children.Methods: Children (3–10 years) undergoing adenotonsillectomy were administered oral clonidine 4 mcg·kg−1mixed with apple fruit drink as premedication.
Peter, Larsson, Anders, Nordlinder, Henrik T G, Bergendahl, Per-Arne, Lönnqvist, Staffan, Eksborg, Nicole, Almenrader, Brian J, Anderson   +6 more
openaire   +2 more sources

Studies of the oral bioavailability of alendronate*

Clinical Pharmacology & Therapeutics, 1995
Clinical studies were performed to examine the oral bioavailability of alendronate (4-amino-1-hydroxy-butylidene-1,1-bisphosphonate monosodium). All studies, with the exception of one performed in men, involved postmenopausal women. Short-term (24 to 36 hours) urinary recovery of alendronate after an intravenous dose of 125 to 250 micrograms averaged ...
B J, Gertz, S D, Holland, W F, Kline, B K, Matuszewski, A, Freeman, H, Quan, K C, Lasseter, J C, Mucklow, A G, Porras   +8 more
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Variable Bioavailability of Oral Melatonin

New England Journal of Medicine, 1997
To the Editor: It has been claimed that melatonin has many actions, mostly on the basis of uncontrolled studies of widely varying oral doses. It is commonly assumed that the administered dosage of melatonin bears a direct relation to its circulating concentration. We estimated the bioavailability of oral melatonin by determining the pharmacokinetics of
W L, Di, A, Kadva, A, Johnston, R, Silman   +3 more
openaire   +2 more sources