Results 251 to 260 of about 1,626,235 (296)

Studies of the oral bioavailability of alendronate*

Clinical Pharmacology & Therapeutics, 1995
Clinical studies were performed to examine the oral bioavailability of alendronate (4-amino-1-hydroxy-butylidene-1,1-bisphosphonate monosodium). All studies, with the exception of one performed in men, involved postmenopausal women. Short-term (24 to 36 hours) urinary recovery of alendronate after an intravenous dose of 125 to 250 micrograms averaged ...
B J, Gertz, S D, Holland, W F, Kline, B K, Matuszewski, A, Freeman, H, Quan, K C, Lasseter, J C, Mucklow, A G, Porras   +8 more
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Bioavailability of oral isbufylline in rabbits

European Journal of Drug Metabolism and Pharmacokinetics, 1992
The bioavailability of isbufylline was assessed in male rabbits given 12 mg/kg i.v. (intravenous) or per os (oral) according to a randomized design. The concentrations of unbound (fu = 54.0) isbufylline were considered in plasma as a function of time, after i.v. and oral administration. After oral administration in saline solution, a mean absolute oral
A, Celardo, G, Dell'Elba, M, Bonati
openaire   +2 more sources

Strategies for enhancing the oral bioavailability of cannabinoids

Expert Opinion on Drug Metabolism & Toxicology, 2022
Oral administration of cannabinoids is a convenient route of administration in many cases. To enhance the poor and variable bioavailability of cannabinoids, selected strategies utilizing proper delivery systems have been designed. Low solubility in the GI aqueous media is the first and most critical barrier.
Ayala, Bar-Hai, Abraham J, Domb, Amnon, Hoffman   +2 more
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Bioavailability and pharmacology of oral idarubicin

Cancer Chemotherapy and Pharmacology, 1991
A total of 9 patients entered in a phase I trial who received oral idarubicin daily for 3 days took part in pharmacokinetic studies, and bioavailability studies were performed on 13 additional patients receiving single doses of oral idarubicin alternating with i.v. treatment.
D J, Stewart, D, Grewaal, R M, Green, S, Verma, J A, Maroun, D, Redmond, L, Robillard, S, Gupta   +7 more
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Linezolid absolute bioavailability and the effect of food on oral bioavailability

Biopharmaceutics & Drug Disposition, 2001
AbstractLinezolid is a novel oxazolidinone antibiotic that has a spectrum of activity encompassing a variety of Gram‐positive bacteria. The objectives of this study were twofold: (1) to compare the absorption of linezolid tablets given immediately following a high‐fat meal with the absorption of tablets administered while fasting, and (2) to assess the
I R, Welshman, T A, Sisson, G L, Jungbluth, D J, Stalker, N K, Hopkins   +4 more
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The Impact of ΔG on the Oral Bioavailability of Low Bioavailable Therapeutic Agents

The Journal of Pharmacology and Experimental Therapeutics, 2005
Low oral bioavailability continues to drive research toward identifying novel approaches to enhance drug delivery. Over the past few years, emphasis on the use of absorption enhancers has been overwhelming despite their major adverse effects. Zonula occludens toxin (Zot) was recently established as a safe and effective absorption enhancer, reversibly ...
Noha N, Salama, Alessio, Fasano, Manjusha, Thakar, Natalie D, Eddington   +3 more
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Bioavailability and Bioavailable Forms of Collagen after Oral Administration to Rats

Journal of Agricultural and Food Chemistry, 2015
The bioavailability and bioavailable forms of collagen after oral administration to rats were investigated in this study. The relative and absolute bioavailability of collagen were 57.8% and 49.6%, respectively, which was indirectly evaluated by the bioavailability of Hyp in collagen using a pharmacokinetic method.
Lin, Wang, Qing, Wang, Jing, Qian, Qiufang, Liang, Zhenbin, Wang, Junmin, Xu, Song, He, Haile, Ma   +7 more
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Bioavailability of Soil-Bound TCDD: Oral Bioavailability in the Rat

Toxicological Sciences, 1988
The implications to the public health of trace amounts of 2,3,7,8-TCDD in the environment are under evaluation by regulatory agencies in the United States and Western Europe. One major consideration in such evaluations is the contribution to human exposure via ingestion of TCDD-contaminated soil.
H, Shu, P, Teitelbaum, A S, Webb, L, Marple, B, Brunck, D, Dei Rossi, F J, Murray, D, Paustenbach   +7 more
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Granules in the improvement of oral heparin bioavailability

International Journal of Pharmaceutics, 2009
Low molecular weight heparins (LMWHs), mainly used for the prevention of deep vein thrombosis, are so far only administered by parenteral route. Presumably, due to their large size and negative charge, LMWHs are not absorbed efficiently across the mucus of the gastrointestinal tract.
Scala-Bertola, J., Rabiskova, M., Lecompte, T., Bonneaux, F., Maincent, P.   +4 more
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In Silico Prediction of Oral Bioavailability

2007
Preclinical predictive models of human oral bioavailability would be of considerable benefit to pharmaceutical product development. Identification of potentially orally bioavailable compounds may assist in candidate selection, or compounds with poor projected bioavailability may be identified early, saving potential late failure and, thus ...
Turner, Joseph, Agatonovic-Kustrin, Snezana   +1 more
openaire   +4 more sources