Results 261 to 270 of about 162,747 (308)
Some of the next articles are maybe not open access.
Pharmacokinetics and Oral Bioavailability of Hydrocortisone
The Journal of Clinical Pharmacology, 1991The pharmacokinetics of 20 mg hydrocortisone were studied after IV and oral administration. Endogenous hydrocortisone was suppressed by dexamethasone administration. Hydrocortisone concentrations were measured in plasma and saliva. After IV administration, hydrocortisone was eliminated with a total body clearance of 18 L/hr and a half‐life of 1.7 hr ...
H, Derendorf +5 more
openaire +2 more sources
Oral bioavailability of mesna tablets
Cancer Chemotherapy and Pharmacology, 1993To test the feasibility of uroprotection with sodium 2-mercaptoethane-sulfonate (mesna) in tablet form the bioavailability of mesna tablets was determined in healthy volunteers by HPLC. The area under the plasma concentration-time curve (AUC) of free mesna was significantly lower following oral (110 mumol.l-1 x h-1; 95% CI 98-122) than following i.v ...
Stofer-Vogel B +3 more
openaire +3 more sources
Bioavailability of oral testosterone in males
European Journal of Clinical Pharmacology, 1979Twenty-six male volunteers received a single oral dose of testosterone as free crystals or as the undecanoate ester. The latter was given either in crystalline form or in arachis oil. All preparations were tested three times in the same individual, whilst fasting on 2 days and on one day together with a breakfast rich in fat.
H, Frey, A, Aakvaag, D, Saanum, J, Falch
openaire +2 more sources
Bioavailability of Oral Melatonin in Humans
Neuroendocrinology, 2008We administered crystalline melatonin (80 mg) in gelatin capsules to 5 young male volunteers and measured serum and urinary melatonin levels at intervals. Changes in serum melatonin levels were best described by a biexponential equation with an absorption constant (k<sub>a</sub>) of 1.72 h-1 (half-life = 0.40 h) and an elimination constant (
F, Waldhauser +5 more
openaire +2 more sources
Absolute bioavailability of oral theophylline
American Journal of Health-System Pharmacy, 1977The absolute bioavailability of theophylline was investigated by comparing the areas under concentration-time curves for intravenous theophylline with a plain uncoated anhydrous theophylline tablet and a theophylline solution. Twenty asthmatic adults received approximately 7.5 mg/kg theophylline intravenously over 30 minutes; either seven days before ...
L, Hendeles, M, Weinberger, L, Bighley
openaire +2 more sources
Bioavailability of Oral and Intramuscular Phenobarbital
The Journal of Clinical Pharmacology, 1978The absorption of phenobarbital was compared in healthy adult subjects after oral and intramuscular therapeutic doses. Serum levels of phenobarbital were determined for 21 days after dosing by means of radioimmunoassay. Serum levels were similar from both dosage routes, with peak levels occurring at 1-3 hours after dosing and then declining slowly with
C T, Viswanathan +2 more
openaire +2 more sources
Predicting Oral Absorption and Bioavailability
2003Publisher Summary The prediction of oral absorption and bioavailability is an important tool, both in the early phases of drug discovery to select the most promising leads for further optimization and in the later stages to select candidates for clinical development.
Han, van de Waterbeemd, Barry C, Jones
openaire +2 more sources
Bioavailability of oral isbufylline in rabbits
European Journal of Drug Metabolism and Pharmacokinetics, 1992The bioavailability of isbufylline was assessed in male rabbits given 12 mg/kg i.v. (intravenous) or per os (oral) according to a randomized design. The concentrations of unbound (fu = 54.0) isbufylline were considered in plasma as a function of time, after i.v. and oral administration. After oral administration in saline solution, a mean absolute oral
A, Celardo, G, Dell'Elba, M, Bonati
openaire +2 more sources
Bioavailability and pharmacology of oral idarubicin
Cancer Chemotherapy and Pharmacology, 1991A total of 9 patients entered in a phase I trial who received oral idarubicin daily for 3 days took part in pharmacokinetic studies, and bioavailability studies were performed on 13 additional patients receiving single doses of oral idarubicin alternating with i.v. treatment.
D J, Stewart +7 more
openaire +2 more sources
Linezolid absolute bioavailability and the effect of food on oral bioavailability
Biopharmaceutics & Drug Disposition, 2001AbstractLinezolid is a novel oxazolidinone antibiotic that has a spectrum of activity encompassing a variety of Gram‐positive bacteria. The objectives of this study were twofold: (1) to compare the absorption of linezolid tablets given immediately following a high‐fat meal with the absorption of tablets administered while fasting, and (2) to assess the
I R, Welshman +4 more
openaire +2 more sources