Results 261 to 270 of about 1,626,235 (296)

Oral Absorption and Bioavailability of Tea Catechins

Planta Medica, 2000
The absorption characteristics and oral bioavailability of three tea catechins, namely (-)-epicatechin (EC), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin gallate (EGCG), were assessed in this study. Male Sprague Dawley rats (210-230 g) received either an intravenous (i.v. 50 mg/kg) or oral (5000 mg/kg) dose of decaffeinated catechin-fraction
M, Zhu, Y, Chen, R C, Li
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The identification of orally bioavailable thrombopoietin agonists

Bioorganic & Medicinal Chemistry Letters, 2009
Recently, we disclosed a series of potent pyrimidine benzamide-based thrombopoietin receptor agonists. Unfortunately, the structural features required for the desired activity conferred physicochemical properties that were not favorable for the development of an oral agent.
Michael J, Munchhof, Amy S, Antipas, Laura C, Blumberg, William H, Brissette, Matthew F, Brown, Jeffrey M, Casavant, Jonathan L, Doty, James, Driscoll, Thomas M, Harris, Lilli A, Wolf-Gouveia, Christopher S, Jones, Qifang, Li, Robert G, Linde, Paul D, Lira, Anthony, Marfat, Eric, McElroy, Mark, Mitton-Fry, Sandra P, McCurdy, Lawrence A, Reiter, Sharon L, Ripp, Andrei, Shavnya, Lisa M, Thomasco, Kristen A, Trevena   +22 more
openaire   +2 more sources

Pharmacokinetics and bioavailability of oral and intramuscular artemether

European Journal of Clinical Pharmacology, 1997
The pharmacokinetics and bioavailability of artemether and dihydroartemisinin were investigated in eight Thai males following the administration of single oral and intramuscular doses of artemether (300 mg) in a randomized two-way cross-over study.Both oral and intramuscular artemether were well-tolerated.
J, Karbwang, K, Na-Bangchang, K, Congpuong, P, Molunto, A, Thanavibul   +4 more
openaire   +2 more sources

Increasing oral bioavailability of progesterone by formulation

Journal of Steroid Biochemistry, 1978
Abstract Admixture of cholesterol trimethyl acetate to progesterone in proportions that formed solid solutions resulted in significant increase of oral bio-availability in humans. Studies in rats have indicated that increased effectiveness was achieved by increasing lymph absorption.
F A, Kincl, L A, Ciaccio, G, Benagiano
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Bioavailability and Pharmacokinetics of Oral Dopamine in Dogs

Journal of Pharmaceutical Sciences, 1988
The bioavailability and pharmacokinetics of oral dopamine (DA) were studied in dogs. Plasma concentrations of DA and its main metabolites, such as dopamine-3-O-sulfate (DA-SO4) and 3,4-dihydroxyphenyl acetic acid (DOPAC) were determined after intravenous or oral administration of DA using high-performance liquid chromatography with electrochemical ...
K, Murata, K, Noda, K, Kohno, M, Samejima   +3 more
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The bioavailability of oral and parenteral chlorimipramine (anafranil)

Progress in Neuro-Psychopharmacology, 1980
1. 1. Ten healthy volunteers were given 50 mg of chlorimipramine orally and intravenously with at least 3 weeks between administrations. 2. 2. Regular estimations of serum chlorimipramine and the metabolite desmethylchlorimipramine were undertaken during the 96 hrs following administration of the drug. 3. 3.
Evans, Larry E.J., Bett, J.H.Nick, Cox, John R., Dubois, Jean P., Van Hees, Thea   +4 more
openaire   +5 more sources

The utility of cyclodextrins for enhancing oral bioavailability

Journal of Controlled Release, 2007
Cyclodextrins (CD) have been utilized extensively in pharmaceutical formulations to enhance oral bioavailability. A critical review of the literature in which cyclodextrins were utilized for this purpose was conducted. The goal of this review was to determine if quantitative guidelines for drug and cyclodextrin properties necessary for bioavailability ...
Rebecca L, Carrier, Lee A, Miller, Imran, Ahmed   +2 more
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Pharmacokinetics and oral bioavailability of carbimide in man

Biopharmaceutics & Drug Disposition, 1991
AbstractA pharmacokinetic study of carbimide, an inhibitor of aldehyde dehydrogenase, used as an adjuvant in the aversive therapy of chronic alcoholism, has been carried out in male human volunteers for intravenous and oral administration.
R, Obach, J, Torrent, H, Colom, J, Pruñonosa, C, Peraire, J, Domenech   +5 more
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The Effect of Mannitol on the Oral Bioavailability of Cimetidine

Journal of Pharmaceutical Sciences, 1995
The aim of the study was to investigate whether mannitol at amounts relevant to pharmaceutical formulations would alter the oral bioavailability of cimetidine, a drug primarily absorbed from the small bowel. Seven healthy male subjects each received four formulations, a chewable tablet or a solution, containing 0.200 g of cimetidine and either 2.264 g ...
D A, Adkin, S S, Davis, R A, Sparrow, P D, Huckle, I R, Wilding   +4 more
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Bioavailability of Oral Physostigmine

New England Journal of Medicine, 1985
R, Whelpton, P, Hurst
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