Results 241 to 250 of about 1,626,235 (296)
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2010
Soil ingestion is a key exposure pathway in Human Health Risk Assessment for contaminants in soil. The theory and mechanisms of how contaminants in a soil enter the human body through the gastrointestinal tract are outlined. The methods available for measuring human exposure using human, animal and validated in-vitro laboratory methods are described ...
Cave, Mark +4 more
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Soil ingestion is a key exposure pathway in Human Health Risk Assessment for contaminants in soil. The theory and mechanisms of how contaminants in a soil enter the human body through the gastrointestinal tract are outlined. The methods available for measuring human exposure using human, animal and validated in-vitro laboratory methods are described ...
Cave, Mark +4 more
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Oral bioavailability of clonidine in children
Pediatric Anesthesia, 2010SummaryBackground: Oral clonidine is used as premedication in children. The bioavailability of clonidine given orally in adults is 75–100% but is unknown in children.Methods: Children (3–10 years) undergoing adenotonsillectomy were administered oral clonidine 4 mcg·kg−1mixed with apple fruit drink as premedication.
Peter, Larsson +6 more
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Variable Bioavailability of Oral Melatonin
New England Journal of Medicine, 1997To the Editor: It has been claimed that melatonin has many actions, mostly on the basis of uncontrolled studies of widely varying oral doses. It is commonly assumed that the administered dosage of melatonin bears a direct relation to its circulating concentration. We estimated the bioavailability of oral melatonin by determining the pharmacokinetics of
W L, Di +3 more
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Absolute bioavailability of oral theophylline
American Journal of Health-System Pharmacy, 1977The absolute bioavailability of theophylline was investigated by comparing the areas under concentration-time curves for intravenous theophylline with a plain uncoated anhydrous theophylline tablet and a theophylline solution. Twenty asthmatic adults received approximately 7.5 mg/kg theophylline intravenously over 30 minutes; either seven days before ...
L, Hendeles, M, Weinberger, L, Bighley
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Bioavailability of Oral and Intramuscular Phenobarbital
The Journal of Clinical Pharmacology, 1978The absorption of phenobarbital was compared in healthy adult subjects after oral and intramuscular therapeutic doses. Serum levels of phenobarbital were determined for 21 days after dosing by means of radioimmunoassay. Serum levels were similar from both dosage routes, with peak levels occurring at 1-3 hours after dosing and then declining slowly with
C T, Viswanathan +2 more
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Bioavailability of Oral Melatonin in Humans
Neuroendocrinology, 2008We administered crystalline melatonin (80 mg) in gelatin capsules to 5 young male volunteers and measured serum and urinary melatonin levels at intervals. Changes in serum melatonin levels were best described by a biexponential equation with an absorption constant (k<sub>a</sub>) of 1.72 h-1 (half-life = 0.40 h) and an elimination constant (
F, Waldhauser +5 more
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Oral bioavailability of mesna tablets
Cancer Chemotherapy and Pharmacology, 1993To test the feasibility of uroprotection with sodium 2-mercaptoethane-sulfonate (mesna) in tablet form the bioavailability of mesna tablets was determined in healthy volunteers by HPLC. The area under the plasma concentration-time curve (AUC) of free mesna was significantly lower following oral (110 mumol.l-1 x h-1; 95% CI 98-122) than following i.v ...
Stofer-Vogel B +3 more
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Bioavailability of oral testosterone in males
European Journal of Clinical Pharmacology, 1979Twenty-six male volunteers received a single oral dose of testosterone as free crystals or as the undecanoate ester. The latter was given either in crystalline form or in arachis oil. All preparations were tested three times in the same individual, whilst fasting on 2 days and on one day together with a breakfast rich in fat.
H, Frey, A, Aakvaag, D, Saanum, J, Falch
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Pharmacokinetics and Oral Bioavailability of Hydrocortisone
The Journal of Clinical Pharmacology, 1991The pharmacokinetics of 20 mg hydrocortisone were studied after IV and oral administration. Endogenous hydrocortisone was suppressed by dexamethasone administration. Hydrocortisone concentrations were measured in plasma and saliva. After IV administration, hydrocortisone was eliminated with a total body clearance of 18 L/hr and a half‐life of 1.7 hr ...
H, Derendorf +5 more
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Predicting Oral Absorption and Bioavailability
2003Publisher Summary The prediction of oral absorption and bioavailability is an important tool, both in the early phases of drug discovery to select the most promising leads for further optimization and in the later stages to select candidates for clinical development.
Han, van de Waterbeemd, Barry C, Jones
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