Results 201 to 210 of about 606,947 (266)

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

Autophagy initiation inhibition combined with chemotherapy reverses drug resistance in oral cancer. [PDF]

Discov Oncol
Li B, Li J, Li S.
europepmc   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Oral Cancer Screening: A Biosocial Analysis of Global Barriers-A Narrative Review of Who Screens, Who Gets Screened, and Why. [PDF]

Cancers (Basel)
Baabdullah RM, Gordon L, Gigliotti J.
europepmc   +1 more source

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source

Emerging Diagnostic Strategies for Oral Cancer and Oral Potentially Malignant Disorders: A PRISMA-Guided Scoping Review. [PDF]

Diagnostics (Basel)
Şengün DN, Faruk Kocamaz Ö, Kitap MC, Soluk Tekkeşin M.   +3 more
europepmc   +1 more source

The Role of Chemopreventive Agents in the Management of Oral Potentially Malignant Disorders and Oral Cancer: A Narrative Review. [PDF]

Cancer Rep (Hoboken)
Sayal L, Hamadah O, Chatty E, Abdo A, Aghbari S, Munasser A, Alnour A.   +6 more
europepmc   +1 more source

Postoperative Unilateral Neck Irradiation for Oral Cancer: Risk Factors for Contralateral Neck Recurrence and Implications for Patient Selection. [PDF]

Cureus
Wakiyama H, Yoshitake T, Matsumoto K, Shirakawa Y, Hisano O, Takaki M, Imafuku H, Matsuo M, Kumamaru W, Kawano S, Ishigami K.   +10 more
europepmc   +1 more source

Research progress on carcinogenic factors and personalized treatment of oral cancer. [PDF]

Discov Oncol
Xu K, Yang Q, Chen W, Li Z, Wu Y, Ren F, Li X.   +6 more
europepmc   +1 more source

Multimodal graphene oxide nanoplatform integrating proteasome inhibition and phototherapy for synergistic oral cancer treatment. [PDF]

Sci Rep
P S S, Sarkar Z, Are V, Chanchlani B, Ghosh A, Biswas S.   +5 more
europepmc   +1 more source