Results 81 to 90 of about 1,238,683 (306)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A sex-dependent salivary bacterium influences oral mucositis severity after allogeneic hematopoietic cell transplantation

npj Biofilms and Microbiomes
The success of allogeneic hematopoietic cell transplantation (alloHCT) in curing hematologic disorders is limited by its short- and long-term toxicities.
Hakan Gem, Maryam Ebadi, Gale Sebastian, Rania Abasaeed, Michele Lloid, Samuel S. Minot, David R. Dean, Armin Rashidi   +7 more
doaj   +1 more source

Oxoglutarate Carrier Inhibition Reduced Melanoma Growth and Invasion by Reducing ATP Production

Pharmaceutics, 2020
Recent findings indicate that (a) mitochondria in proliferating cancer cells are functional, (b) cancer cells use more oxygen than normal cells for oxidative phosphorylation, and (c) cancer cells critically rely on cytosolic NADH transported into ...
Jae-Seon Lee, Jiwon Choi, Seon-Hyeong Lee, Joon Hee Kang, Ji Sun Ha, Hee Yeon Kim, Hyonchol Jang, Jong In Yook, Soo-Youl Kim   +8 more
doaj   +1 more source

Oral Cancer

Journal of Student Research, 2022
Oral cancer or mouth cancer is a type of cancer that forms in the oral cavity, resulting in the uncontrolled growth of abnormal cells that damage the surrounding tissue. There are several factors that accelerate oral cancer, including human papillomavirus (HPV) infections, genetic influences, UV light and substance use.
Radaporn Chutanopmanee, Sirayawadee Maneesilp, Nonthasorn Wongsirilert, Jason Zhang   +3 more
openaire   +1 more source

Cancer Surveillance using Data Warehousing, Data Mining, and Decision Support Systems [PDF]

, 2000
This article discusses how data warehousing, data mining, and decision support systems can reduce the national cancer burden or the oral complications of cancer therapies, especially as related to oral and pharyngeal cancers.
Adya, Monica, Forgionne, Guisseppi A., Gangopadhyay, Aryya   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Stability of standardized uptake values for quantitative bone SPECT for jawbone lesions: a single-center cross-sectional study

BMC Oral Health
Background The long time required for bone uptake of radiopharmaceutical material after injection for bone scintigraphy is a burden for patients with poor health.
Hironobu Hata, Satoshi Shimomura, Kenji Imamachi, Jun Sato, Takuya Asaka, Kenji Hirata, Kyousuke Funayama, Yoichi Mori, Masashi Matsuzaka, Toshikazu Nambu, Yoshimasa Kitagawa   +10 more
doaj   +1 more source

Asiatic Acid, Extracted from Centella asiatica and Induces Apoptosis Pathway through the Phosphorylation p38 Mitogen-Activated Protein Kinase in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells

Biomolecules, 2020
Nasopharyngeal carcinoma (NPC) is an important issue in Asia because of its unique geographical and ethnic distribution. Cisplatin-based regimens are commonly the first-line used chemotherapy, but resistance and toxicities remain a problem.
Yen-Tze Liu, Yi-Ching Chuang, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ting Hsi, Ming-Ju Hsieh, Mu-Kuan Chen   +6 more
doaj   +1 more source

Oral ethinylestradiol in castration resistent prostate cancer: 10 year experience [PDF]

, 2015
To describe our 10-year experience with the use of oral ethinylestradiol in the treatment of metastatic castration-resistant prostate cancer. METHODS: From February 2000 to April 2010, 116 patients with a metastatic castration-resistant prostate cancer
Aggarwal, Beer, Bonkhoff, Bono, Chadha, Corey, Di Silverio, Gasent Blesa, Izumi, Kitahara, Limonta, Montgomery, Shamash, Stein, Takezawa, Tannock, Wilkins   +16 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source