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Oral Cholera Vaccine Efficacy and Effectiveness. [PDF]

Vaccines (Basel), 2021
Although measuring vaccine efficacy through the conventional phase III study design, randomized, double-blinded controlled trial serves as the “gold standard”, effectiveness studies, conducted in the context of a public health program, seek to broaden the understanding of the impact of a vaccine in a real world setting including both individual and ...
Song KR, Lim JK, Park SE, Saluja T, Cho SI, Wartel TA, Lynch J.   +6 more
europepmc   +8 more sources

An overview of VaxchoraTM, a live attenuated oral cholera vaccine [PDF]

Human Vaccines & Immunotherapeutics, 2020
Cholera remains a public health threat among the least privileged populations and regions affected by conflicts and natural disasters. Together with Water, Sanitation and Hygiene practices, use of oral cholera vaccines (OCVs) is a key tool to prevent ...
Tarun Saluja, Vijayalaxmi V. Mogasale, Jean-Louis Excler, Jerome H. Kim, Vittal Mogasale   +4 more
doaj   +4 more sources

Uptake likelihood assessment of oral cholera vaccine capsules: insights from stakeholder consultations in five countries [PDF]

BMC Public Health
Background The global resurgence of cholera, a diarrhoeal disease, has resulted in vaccine demand that exceeds the currently available supply resulting in global calls for next generation cholera vaccines.
Dijana Spasenoska, Anna-Lea Kahn, Malika Bouhenia, Naveena Aloysia D’Cor, Jung-Seok Lee, Se Eun Park, Julia Lynch   +6 more
doaj   +2 more sources

Stockpiling oral cholera vaccine

Bulletin of the World Health Organization, 2012
Cholera is re-emerging as a threat on the global public health stage. The number of reported cases worldwide is back at the peak level observed two decades ago,1 new Vibrio cholerae strains have appeared and antimicrobial resistance has increased. Weak surveillance systems and the possibility of travel and trade sanctions contribute to widespread ...
Stephen Martin, Alejandro Costa, William Perea   +2 more
doaj   +3 more sources

Effectiveness of two doses of Euvichol-plus oral cholera vaccine in response to the 2017/2018 outbreak: a matched case–control study in Lusaka, Zambia [PDF]

BMJ Open, 2022
Introduction Zambia experienced a major cholera outbreak in 2017–2018, with more than 5905 cases reported countrywide, predominantly from the peri-urban slums of Lusaka city.
Victor M Mukonka, Modest Mulenga, C Michelo, Khozya Zyambo, Cephas Sialubanje, Muzala Kapina, Orbrie Chewe, Belem Blamwell Matapo, Albertina Moraes Ngomah, Brittany Gianetti, William Ngosa, Mpanga Kasonde, Kunda Musonda, Nyambe Sinyange, Patricia Bobo, Lucy Mazyanga, Nathan Bakyaita   +16 more
doaj   +2 more sources

Knowledge and perception of a clinical trial among the participants: An experience from oral cholera vaccine study in Koshi Province, Nepal [PDF]

Human Vaccines & Immunotherapeutics
Clinical trials (CT) have been the cornerstones in developing medicines, vaccines, and new interventions. Despite tremendous efforts, a CT cannot succeed without participants’ involvement. Various factors can affect people’s attitude and participation in
Shipra Chaudhary, Surendra Uranw, Basant Rai, Nisha Keshary Bhatta, Gauri Shankar Shah, Prakash Poudel, Basudha Khanal, Rosan Prasad Shah Kalawar, Nikita Rai, Jenisha Shrestha, Merina Shrestha, Shalu Parajuli, Birendra Prasad Gupta, Sridhar Vemula, Katerina Rok Song, Julia Lynch, Tarun Saluja   +16 more
doaj   +2 more sources

Costing oral cholera vaccine delivery using a generic oral cholera vaccine delivery planning and costing tool (CholTool). [PDF]

Hum Vaccin Immunother, 2020
Cholera is both an endemic and epidemic disease in many low and middle-income countries (LMICs). Strategies for cholera control include improving water, sanitation, and hygiene; providing early and effective treatment; and deploying oral cholera vaccine (OCV).
Morgan W, Levin A, Hutubessy RC, Mogasale V.   +3 more
europepmc   +5 more sources

Epidemiologic and Genomic Surveillance of Vibrio cholerae and Effectiveness of Single-Dose Oral Cholera Vaccine, Democratic Republic of the Congo [PDF]

Emerging Infectious Diseases
We conducted 4 years of epidemiologic and genomic surveillance of single-dose effectiveness of a killed whole-cell oral cholera vaccine (kOCV) and Vibrio cholerae transmission in the Democratic Republic of the Congo.
Christine Marie George, Alves Namunesha, Kelly Endres, Willy Felicien, Presence Sanvura, Jean-Claude Bisimwa, Jamie Perin, Justin Bengehya, Jean Claude Kulondwa, Ghislain Maheshe, Cirhuza Cikomola, Lucien Bisimwa, Alain Mwishingo, David A. Sack, Daryl Domman   +14 more
doaj   +2 more sources

Vaccination strategies to combat an infectious globe: Oral cholera vaccines

Journal of Global Infectious Diseases, 2011
Cholera is a substantial health burden in many countries in Africa and Asia, where it is endemic. It is as well responsible for ongoing epidemics in sub-Saharan Africa which are becoming greater in terms of frequency, extension, and duration.
Rosa M López-Gigosos, Elena Plaza, Rosa M Díez-Díaz, Maria J Calvo   +3 more
doaj   +3 more sources

Study protocol for cholera vaccination as a model to measure the inflammatory response in the gut: A case of modulation with a Lactobacillus plantarum K8 lysate

PLoS ONE, 2023
It is crucial for human health that the immune system of the gastrointestinal tract works effectively. Dietary modulation is one of the factors that regulate the immune response in the gut. This study aims to develop a safe human challenge model to study
Min Young Park, Soo-yeon Park, Anita Hartog, Els van Hoffen, Alwine Kardinaal, Joohee Kim, Hee Jung Choi, Oran Kwon, Ji Yeon Kim   +8 more
doaj   +2 more sources