Results 71 to 80 of about 4,484,225 (267)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

เทคโนโลยีการผลิตเภสัชภัณฑ์แตกตัวในช่องปาก Oral Disintegrating Dosage Forms Technologies [PDF]

, 2013
บทคัดย่อ รูปแบบการบริหารยาโดยการรับประทานเป็นรูปแบบที่นิยมใช้มากที่สุด เนื่องจาก มีความปลอดภัยสูง ง่ายและสะดวก รวมทั้งได้รับความร่วมมือในการใช้ยาจาก ผู้ป่วย นอกจากนี้รูปแบบเภสัชภัณฑ์ของแข็งยังเป็นที่ยอมรับจากผู้ป่วยอย่าง แพร่หลายทัง้ ผู้ใหญ่และวัยรุ่น ...
สัมประสิทธิ์, วิภาดา, โอปณะโสภิต, ปราณีต   +1 more
core  

SILYMARIN FOOD SUPPLEMENTS – ORAL SOLID DOSAGE FORMS

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2016
Several tablet formulations containing silymarin were developed, in order to meet the requirements of different markets. Milk thistle - Silybum marianum (L.) Gaertn – standardized extracts have proven their positive effect on liver functionality plus ...
FELICIA G. GLIGOR , CARMEN M. DOBREA, CECILIA GEORGESCU , LOREDANA A. VONICA GLIGOR, ADINA FRUM, MARIA TOTAN   +5 more
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Desenvolvimento e validação de métodos para quantificação e dissolução de buclizina em associação para as formas farmacêuticas comprimidos e suspensão oral [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2010O cloridrato de buclizina (BCZ) está entre os fármacos mais utilizados como estimulantes do apetite e ...
Kuminek, Gislaine
core  

Mapping current trends in 3D printing and the impact on the recent landscape of drug development research

British Journal of Pharmacy, 2018
Three Dimensional (3D) printing within the pharmaceutical industry is rapidly developing and current trends within drug development include the 3D printing of oral dosage forms, implants, hydrogels and topical drug delivery systems.
Craig Russell , Harriet Hampshire
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

BIOAVAILABILITY OF VALSARTAN LIQUID ORAL DOSAGE FORMS

, 2013
The oral bioavailability of valsartan from extemporaneous suspension and solution formulation was evaluated relative to tablet formulation in two separate open label, randomize crossover studies in healthy adults.
Gangadhar Sunkara, Anisha E. Mendonza, Jimmy Flarakos, Neelakantham, Srikanth, Biswal, Shibadas, Zhang, Yiming, Solar-Yohay, Susan, Venkateswar Jarugula, Flarakos, Jimmy, Girish Bende, Susan Solar‐Yohay, Mendonza, Anisha, Srikanth Neelakantham, Robert Wagner, Jarugula, Venkateswar, Yiming Zhang, Bende, Girish, Sunkara, Gangadhar, Wagner, Robert, Shibadas Biswal   +19 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source