Results 51 to 60 of about 6,104,462 (286)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]

, 2013
The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Muller, Daniel J, Myllymäki, Satu M., Jens Friedrichs, Aki Manninen (221960), Matlin, Karl S., Daniel J. Muller (2509858), Manninen, Aki, Myllymäki Satu M., Manninen Aki, Jose V Moyano, Strohmeyer, Nico; id_orcid, Teräväinen, Terhi P, Muller Daniel J., Terhi P. Teräväinen (447383), Jens Friedrichs (447385), Muller, Daniel J., Satu M Myllymäki, Engler, Adam J., Friedrichs Jens, Chuanyue Wu (196653), Satu M. Myllymäki (447384), Strohmeyer, Nico, Nico Strohmeyer (447386), Karl S. Matlin (447388), Moyano, Jose V, Teräväinen, Terhi P., Terhi P Teräväinen, Karl S Matlin, Chuanyue Wu, Wu, Chuanyue, Moyano, Jose V., Strohmeyer Nico, Myllymäki, Satu M, Aki Manninen, Daniel J Muller, Jose V. Moyano (447387), Matlin Karl S., Wu Chuanyue, Moyano Jose V., Nico Strohmeyer, Matlin, Karl S, Friedrichs, Jens, Teräväinen Terhi P.   +42 more
core   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Function of Gata-2 in thymic epithelial cells : a transcription factor identified from gene expression analysis of endodermal cells committed to thymic epithelial cell fate [PDF]

, 2010
The thymus structure composes of clear morphological regions. The T-cell precursors enter the thymus in the cortico-medullary junction and migrate through the cortex towards the sub capsular region and back through to the cortex into the medulla.
Na, Kyung-Jae
core   +1 more source

Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells

BMC Complementary and Alternative Medicine, 2012
Background Oral candidiasis is a common fungal disease mainly caused by Candida albicans. The aim of this study was to investigate the effects of A-type cranberry proanthocyanidins (AC-PACs) on pathogenic properties of C.
Feldman Mark, Tanabe Shinichi, Howell Amy, Grenier Daniel   +3 more
doaj   +1 more source

Role of Mast Cells in Progression of Oral Epithelial Dysplasia

RUHS Journal of Health Sciences, 2023
Introduction: Mast cells (MC) are the local residents of the connective tissue and are associated with the release of certain pro-inflammatory and mitogenic cytokines.
Shikha Saxena; Priyanka Singh; Akshay Bhargava; Krishna Sireesha Sundaragiri; Chandni Shekhawat; Bharat Sankhla
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Immunoexpression of cytokeratin 19 in oral swab from fixed orthodontic appliance users

Padjadjaran Journal of Dentistry, 2007
The use of fixed orthodontic appliances can improve someone's mastication, speech and appearance. However, this appliance acts as a strange object that may cause irritation to the mucosa epithelial of oral cavity, because of the friction and pressure ...
Dwi Mutia Ramdhini, S. Sunardhi Widyaputra, Murnisari Dardjan   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity [PDF]

, 2011
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis.
Königshoff, M., Melanie Königshoff, Königshoff, Melanie   +2 more
core   +1 more source