Results 101 to 110 of about 1,433,667 (207)

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA)

Arthritis &Rheumatology, Accepted Article.
Objectives The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing (RNAseq) in vastus lateralis muscle, resulting in 523 participants (56% female ...
Daniel S. Evans, Tyler A. Mansfield, Gina M. Many, Tyler J. Sagendorf, Samaneh Farsijani, Bret H. Goodpaster, Lauren M. Sparks, Nancy E. Lane   +7 more
wiley   +1 more source

Effects of a Modified Hospital Elder Life Program on Frailty in Individuals Undergoing Major Elective Abdominal Surgery

, 2017
ObjectivesTo test the effects of a modified Hospital Elder Life Program (mHELP) on frailty. DesignMatched and unmatched analyses of data from a before-and-after study. SettingHospital, inpatient.
陳佳慧;賴逸儒;陳炯年, Chen, Cheryl Chia-Hui;Chen, Chiung-Nien;Lai, I-Rue;Huang, Guan-Hua;Saczynski, Jane S.;Inouye, Sharon K.   +1 more
core   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

The current status and influencing factors of oral frailty in elderly maintenance hemodialysis patients based on the Andersen Oral Health Outcome Model

BMC Oral Health
Objectives To analyse the elements that influence oral frailty in elderly maintenance hemodialysis patients and to comprehend the present state of this condition.
Meiqian Chen, Mingqian He, Qingxin Gu, Xinru Gao, Guanzhen Lu   +4 more
doaj   +1 more source

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Factors correlated to oral frailty and number of remaining teeth among 80-year-old population in Japan

BMC Geriatrics
Background Oral frailty is proposed as a new concept defined as an age-related gradual loss of oral functions accompanied by a decline in cognitive and physical functions in older adults.
Naofumi Tamaki, Takatoshi Hiroshimaya, Kazuto Fukuhara, Hiroshi Ijichi   +3 more
doaj   +1 more source

Association Between Oral Health and Physical Frailty in an Adult Community-Dwelling Caucasian Population.

Background Although oral diseases and frailty can be met earlier in life, there is limited information on their association across the lifespan.Objectives To scope for the association of oral factors with physical frailty in Greek community-dwelling ...
Kossioni, Anastassia, Schimmel, Martin, Polychronopoulou, Argy, Falidea, Natalia, Kotsani, Marina, Soulis, George, Konstantopoulou, Kalliopi   +6 more
core   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Oral Frailty as a Risk Factor for Fall Incidents among Community-Dwelling People

Geriatrics
Background: Identifying older adults with a high risk of falling and providing them with appropriate intervention are vital measures for preventing fall incidents.
Hisayo Yokoyama, Yugo Kitano
doaj   +1 more source