Results 121 to 130 of about 1,433,667 (207)

Investigating the role of frailty in the expression of dementia

open access: yes, 2020
Background: Frailty is related to neuropathological features of Alzheimer’s disease (AD) as well as cognitive decline and dementia. Objectives: 1) determine whether frailty moderates the relationship between neuropathology and dementia status in ...
Wallace, Lindsay M K
core  

Experimental methods in chemical engineering: The scientific method versus engineering design methodology

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Abstract Engineering graduate students confuse the scientific method and problem solving when presenting their pre‐doctoral exams and theses: Science discourse adopts question and hypotheses to assert and establish a study's rationale, while it is problem and objectives in engineering design.
Gregory S. Patience   +4 more
wiley   +1 more source

Prevalence of oral frailty in community-dwelling older adults: a systematic review and meta-analysis

open access: yesFrontiers in Public Health
BackgroundOlder adults are vulnerable to oral frailty due to factors such as age, education level, physical condition, and limited access to medical resources.
Jun-kai Dou   +6 more
doaj   +1 more source

Defining Biomarkers of Frailty in the Kidney: Implications for Endobiotic and Xenobiotic Metabolism in Mice

open access: yes, 2023
Frailty describes individuals with increased susceptibility to adverse health outcomes. The frailty index (FI) quantifies frailty by measuring deficit accumulation. This project aimed to characterize the molecular signature of frailty in the mouse kidney
Hodgins, Maddison
core  

Physiologically Based Pharmacokinetic Modeling to Assess Transporter‐Mediated Drug–Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Alice Ke   +8 more
wiley   +1 more source

Oral frailty and its influencing factors in patients with cancer undergoing chemotherapy: a cross-sectional study

open access: yesBMC Oral Health
Background Oral frailty is one of the easily overlooked complications in patients with cancer, which is as important as dietary dysfunction, malnutrition and other complications. However, limited research exists on the factors influencing oral frailty in
Fangyi Li   +10 more
doaj   +1 more source

Outpatient treatment of decompensated heart failure: A systematic review and study level meta‐analysis

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 761-769, April 2025.
Abstract Patients with acutely decompensated heart failure (ADHF) are usually admitted to hospital for management. There is growing interest in delivering intravenous (IV) diuretic therapy at home, in the community or at hospital day‐care units; the safety and effectiveness of outpatient‐based management (OPM) for ADHF has not been established.
Jameela Bahar   +13 more
wiley   +1 more source

Comparing Virtual and Center Based Cardiac Rehabilitation on Changes in Frailty

open access: yes, 2022
This is a paper-based thesis, however, the manuscript (Chapter 4) has not been submitted to an academic journal at the time of submitting this thesis.Cardiac rehabilitation (CR) is the gold standard for the secondary prevention of cardiovascular disease (
MacEachern, Evan
core  

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang   +7 more
wiley   +1 more source

Expression of p21WAF1/CIP1 is unrelated to p53 tumour suppressor gene status in oral squamous cell carcinomas

open access: yes, 1998
The p53 tumour suppressor gene is frequently mutated in oral squamous cell carcinomas. However, the downstream mechanism of p53 during oral carcinogenesis is not fully understood.
육종인, 김진
core   +1 more source

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