Results 151 to 160 of about 11,814,383 (250)

Nutritional and environmental determinants of maturation and disruption of the early life gut microbiome: A narrative review

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract The first 1000 days of life represent a critical window for gut microbiome assembly, with lifelong implications for child growth, immune development, and disease risk. This review synthesizes evidence on maternal, perinatal, and especially nutritional factors that influence early‐life intestinal colonization and highlights the consequences of ...
Carly Burow, Romy Shenderey, Fariha Chowdhury, Nyah Shah, Nikhil Pai   +4 more
wiley   +1 more source

Outcomes of pharmacist‐led deprescribing interventions in older adults living in long‐term care facilities: a scoping review

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background An increase in the ageing population across long‐term care facilities (LTCFs) has led to an increased risk of polypharmacy. Pharmacist‐led deprescribing (PLD) can reduce these risks but there are limitations to its widespread uptake.
Sefunmi Odetola, Eileen Willis, Katrina Lane‐Krebs, Ashlyn Sahay   +3 more
wiley   +1 more source

A comparative analysis of the prevalence of medicine classes and polypharmacy between community‐dwelling and residential aged care populations in Western Australia

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Polypharmacy is a global issue, particularly among residential aged care home (RACH) residents with multimorbidity and complex care needs. However, population‐level evidence on longitudinal trends and comparisons with community‐dwelling (CD) older adults remains limited.
David Lim, Ninh Ha, David Youens, Rachael Moorin, Andrew Stafford   +4 more
wiley   +1 more source

Effects of paraprobiotic Lactobacillus acidophilus LA‐5 on PANoptosis, oxidative stress and inflammation in acetic acid‐induced ulcerative colitis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Ulcerative colitis (UC) is a relapsing inflammatory bowel disease characterised by oxidative stress, inflammation and regulated cell death of the colonic mucosa. Because live probiotics may cause bacteraemia and sepsis in immunocompromised hosts, non‐viable (paraprobiotic) alternatives have attracted interest.
Adem Yavaş, Ezgi Özkıran, Ecem Akan
wiley   +1 more source

Association between frailty and oral function in rheumatoid arthritis patients: A multi-center, observational study

The Turkish Journal of Gastroenterology
Objectives: This study aims to investigate the association between frailty and oral function in rheumatoid arthritis (RA) patients and to identify practical markers for early frailty detection and potential intervention strategies.
Yasumori Sobue, Shuji Asai, Kenya Terabe, Takaya Sugiura, Junya Hasegawa, Yusuke Ohno, Ryo Sato, Yoshifumi Ohashi, Mochihito Suzuki, Shiro Imagama   +9 more
doaj  

Rhaponticin Blocks Glycolysis‐Mediated Histone Lactylation to Suppress Tongue Squamous Cell Carcinoma via HIF‐1α Activity Inhibition

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma (TSCC) often develops therapeutic resistance. Metabolic reprogramming, particularly the glycolysis/lactate/histone lactylation axis, is a critical driver of tumor progression and therapy resistance. This study investigated the anti‐tumor mechanism of Rhaponticin (Rha), focusing on the metabolic/epigenetic axis ...
Yuan Wu, Liang‐Liang Yao, Lin Jiang, Zhi‐Yi Fang, Jia‐Jun Zhu, Yi‐Sen Shao, Wen‐Juan Wang, Xiao‐Wen Wan   +7 more
wiley   +1 more source

Managing the meniscus part I—Anatomy, biomechanics, and treatment strategies for the atraumatic meniscus tear

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The purpose of this article is to serve as the first of a two‐part review on the meniscus; in this review, we will establish the background on anatomy and pathogenesis of the meniscus, as well as the effect of the meniscus on native knee kinematics and function.
Ehab M. Nazzal, Jonathan D. Hughes, Armin Runer, Matthew P. Kolevar, Jorge Chahla, Robert G. Marx, James J. Irrgang, Roman Seil, Berte Bøe, David Parker, Ryosuke Kuroda, Eric H. Senorski, Sachin Tapasvi, Volker Musahl   +13 more
wiley   +1 more source

Unintentional Weight Loss Does Not Predict Poor Outcomes in Zenker Diverticulum

The Laryngoscope, EarlyView.
In this study of 427 patients with Zenker's diverticulum, 23.6% had significant unintentional preoperative weight loss. Weight loss was associated with preoperative dysphagia and with both the smallest and largest pouches. Postoperative outcomes were similar in patients with and without weight loss, demonstrating a similar efficacy and safety profile ...
Ari D. Schuman, Jacqui Allen, Mekibib Altaye, Milan R. Amin, Semirra L. Bayan, Peter C. Belafsky, Brad W. DeSilva, Shumon I. Dhar, Dale C. Ekbom, Aaron D. Friedman, Mark Fritz, Glendon M. Gardner, Elizabeth A. Guardiani, Christopher Johnson, Jan Kasperbauer, Brandon Kim, Brittany N. Krekeler, Maggie A. Kuhn, Yue Ma, Lyndsay L. Madden, Laura Matrka, Ross M. Mayerhoff, Cyrus Piraka, Apoorva Ramaswamy, Clark A. Rosen, Haley C. Sibley, Meredith Tabangin, Carter Wright, Z. Mike Yang, Vyvy N. Young, Gregory Postma, Rebecca J. Howell   +31 more
wiley   +1 more source

Novel biomarkers of frailty in middle-aged and older females

The burden of frailty and its associated health complications, including cardiovascular disease, is becoming a critical health concern. Frailty is a multifactorial physiological decline that increases vulnerability to health stressors.
Boreskie, Kevin
core  

Impact of Frailty on Surgical Outcomes in Patients Treated for Cricopharyngeus Muscle Dysfunction

The Laryngoscope, EarlyView.
ABSTRACT Objective To investigate the relationship between frailty status and surgical outcomes in patients undergoing procedures for cricopharyngeus muscle dysfunction (CPMD). Methods Retrospective chart review of all patients who underwent upper esophageal sphincter (UES) interventions at a tertiary dysphagia center.
Jessa Letargo, Ramey Kharfan, Charmaine Szalay‐Anderson, Derrick R. Randall   +3 more
wiley   +1 more source