Results 51 to 60 of about 11,814,383 (250)

Analysis of the current status and influencing factors of oral frailty in elderly patients with type 2 diabetes mellitus in Taiyuan, China

BMC Geriatrics
Background This study aimed to investigate the current status of oral frailty in elderly patients with type 2 diabetes mellitus (T2DM) and analyze its influencing factors. Methods We recruited 464 elderly T2DM patients from a tertiary hospital in Taiyuan,
Chun Tian, Na Li, Ya Gao, Yan Yan
doaj   +1 more source

Prevalence and influencing factors of oral frailty among middle-aged and older patients with chronic kidney disease: a cross-sectional study

Frontiers in Medicine
BackgroundOral health has emerged as a subject of significant public concern. Oral frailty represents the clinical presentation of advanced oral health decline and serves as a significant indicator of systemic frailty.
Yuelin Wang, Zengli Chen, Qing Tang, Yunlan Jiang, Qianqian Cong, Hong Chen, Lunhui Wu   +6 more
doaj   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

Advanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang, Shaowen Zhuo, Binyu Song, Jinan Chen, Xin Zhao, Sijia Li, Shuang You, Dong Jiang, Yuedong Chen, Juanli Dang, Tong Wang, Baolin Guo, Zhou Yu, Baoqiang Song   +13 more
wiley   +1 more source

Relationship between risk of oral frailty and awareness of oral frailty among community-dwelling adults: a cross-sectional study

Scientific Reports
We aimed to investigate the relationship between the risk of oral frailty and awareness of oral frailty among Japanese adults in an adult dental health field study conducted in Kanagawa Prefecture.
Koichiro Irie, Yuki Mochida, Nandin Uchral Altanbagana, Shinya Fuchida, Tatsuo Yamamoto   +4 more
doaj   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Associated factors of oral frailty in older adults with long-term T2DM duration of more than 10 years

BMC Geriatrics
Objective To identify the factors that affect oral frailty in older adults with type 2 diabetes mellitus (T2DM) with long-term disease duration of more than 10 years.
Jian Yu, Anna Ye, Yang Fei, Dandan Wang, Yu Zhang, Xianwen Li   +5 more
doaj   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Child-OIDP index in Brazil: Cross-cultural adaptation and validation [PDF]

, 2008
Background: Oral health-related quality of life (OHRQoL) measures are being increasingly used to introduce dimensions excluded by normative measures. Consequently, there is a need for an index which evaluates children's OHRQoL validated for Brazilian ...
Sheiham Aubrey, Cortes, MIS, Souza, IPR, Portela Margareth C, Marcenes Wagner, Leao, AT, Leão Anna T, Castro, RAL, Sheiham, A, Cortes Maria IS, Castro Rodolfo AL, Tsakos, G, Marcenes, W, Portela, MC, Tsakos Georgios, Souza Ivete PR   +15 more
core   +1 more source